The blood–brain barrier (BBB) is one of the most complex and selective barriers in the
human organism. Its role is to protect the brain and preserve the homeostasis of the central …

The blood-brain barrier (BBB) is one of the most essential protection mechanisms in the
central nervous system (CNS). It selectively allows individual molecules such as small lipid …

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Introduction: Desired clinical outcome of pharmacotherapy of brain diseases largely …

Small interfering RNA (siRNA)-based gene silencing technology has demonstrated
significant potential for treating brain-associated diseases. However, effective and safe …

Physiological characteristics of diseases bring about both challenges and opportunities for
targeted drug delivery. Various drug delivery platforms have been devised ranging from …

Neuroinflammation is a hallmark of neurodegenerative disorders including Alzheimer's
disease (AD). Microglia, the brain's immune cells, express many of the AD‐risk loci identified …

Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide and its
incidence is increasing due to the ageing population. Currently, the main limitations of AD …

Cerebral ischemia/reperfusion (I/R) results in harmful consequences during ischemic stroke,
especially the disruption of the blood–brain barrier (BBB), which leads to severe …

Tetramethylpyrazine (TMP) has been studied in depth and is widely used in the treatment of
many kinds of diseases in China. However, whether it has neuroprotective effects on …

Introduction: Viral and non-viral vectors have been used as methods of delivery in gene
therapy for many CNS diseases. Currently, viral vectors such as adeno-associated viruses …