Myelin is critical for the proper function of the nervous system and one of the most complex
cell–cell interactions of the body. Myelination allows for the rapid conduction of action …

Myelin is essential to nervous system function, playing roles in saltatory conduction and
trophic support. Oligodendrocytes (OLs) and Schwann cells (SCs) form myelin in the central …

Myelinating cells surround axons to accelerate the propagation of action potentials, to
support axonal health, and to refine neural circuits. Myelination is metabolically demanding …

Following peripheral nerve injury (PNI), Wallerian degeneration (WD) in the distal stump can
generate a microenvironment favorable for nerve regeneration. Brief low‐frequency …

Highlights•Remak Schwann cells ensheath multiple small caliber axons.•Remak Schwann
cells are critical for peripheral nerve development, maintenance, and regeneration.•Genetic …

Glial cells in the peripheral nervous system (PNS), which arise from the neural crest, include
axon-associated Schwann cells (SCs) in nerves, synapse-associated SCs at the …

Loss of the Merlin tumor suppressor and activation of the Hippo signaling pathway play
major roles in the control of cell proliferation and tumorigenesis. We have identified …

Myelination is a biosynthetically demanding process in which mTORC1, the gatekeeper of
anabolism, occupies a privileged regulatory position. We have shown previously that loss of …

Although diabetic mice have been studied for decades, little is known about the cell type
specific contributions to diabetic neuropathy (DN). Schwann cells (SCs) myelinate and …

Haplo-insufficiency of the gene encoding the myelin protein PMP22 leads to focal myelin
overgrowth in the peripheral nervous system and hereditary neuropathy with liability to …