[HTML][HTML] Phosphoproteomics in cancer
Reversible protein phosphorylation serves as a basis for regulating a number of cellular
processes. Aberrant activation of kinase signaling pathways is commonly associated with …
processes. Aberrant activation of kinase signaling pathways is commonly associated with …
Technological advances for interrogating the human kinome
There is increasing appreciation among researchers and clinicians of the value of
investigating biology and pathobiology at the level of cellular kinase (kinome) activity …
investigating biology and pathobiology at the level of cellular kinase (kinome) activity …
[HTML][HTML] HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer
Herceptin (trastuzumab) is used in patients with breast cancer who have HER2 (ErbB2)–
positive tumours. However, its mechanisms of action and how acquired resistance to …
positive tumours. However, its mechanisms of action and how acquired resistance to …
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation
The phosphatase and tensin homolog (PTEN) is a tumor suppressor that is inactivated in
many human cancers. PTEN loss has been associated with resistance to inhibitors of the …
many human cancers. PTEN loss has been associated with resistance to inhibitors of the …
Profiling activity of cellular kinases in migrating T-cells
CS Chirumamilla, MHUT Fazil, C Perez-Novo… - T-Cell Motility: Methods …, 2019 - Springer
T-Lymphocyte kinases are important checkpoints that control T-cell motility by regulating a
diverse range of signal transduction pathways. The distinct configuration of kinase events in …
diverse range of signal transduction pathways. The distinct configuration of kinase events in …
Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non–small cell lung cancer
I Kawada, R Hasina, Q Arif, J Mueller, E Smithberger… - Cancer research, 2014 - AACR
Lung cancer is a heterogeneous disease encompassing a wide array of genetic
abnormalities. The MET receptor tyrosine kinase is altered in many lung cancers, especially …
abnormalities. The MET receptor tyrosine kinase is altered in many lung cancers, especially …
[HTML][HTML] Protein kinase activity decreases with higher Braak stages of Alzheimer's disease pathology
AFN Rosenberger, R Hilhorst, E Coart… - Journal of …, 2016 - content.iospress.com
Alzheimer's disease (AD) is characterized by a long pre-clinical phase (20–30 years), during
which significant brain pathology manifests itself. Disease mechanisms associated with …
which significant brain pathology manifests itself. Disease mechanisms associated with …
Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling
S Folkvord, K Flatmark, S Dueland, R De Wijn… - International Journal of …, 2010 - Elsevier
PURPOSE: Tumor response of rectal cancer to preoperative chemoradiotherapy (CRT)
varies considerably. In experimental tumor models and clinical radiotherapy, activity of …
varies considerably. In experimental tumor models and clinical radiotherapy, activity of …
Peptide microarrays for profiling of serine/threonine kinase activity of recombinant kinases and lysates of cells and tissue samples
R Hilhorst, L Houkes, M Mommersteeg, J Musch… - … : Methods and Protocols, 2013 - Springer
Peptide microarray technology can be used to identify substrates for recombinant kinases, to
measure kinase activity and changes thereof in cell lysates and lysates from fresh frozen …
measure kinase activity and changes thereof in cell lysates and lysates from fresh frozen …
[HTML][HTML] High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypes
Despite the widespread use of kinase-targeted agents in clear cell renal cell carcinoma (CC-
RCC), comprehensive kinase activity evaluation (kinomic profiling) of these tumors is …
RCC), comprehensive kinase activity evaluation (kinomic profiling) of these tumors is …