Reversible protein phosphorylation serves as a basis for regulating a number of cellular
processes. Aberrant activation of kinase signaling pathways is commonly associated with …

There is increasing appreciation among researchers and clinicians of the value of
investigating biology and pathobiology at the level of cellular kinase (kinome) activity …

Herceptin (trastuzumab) is used in patients with breast cancer who have HER2 (ErbB2)–
positive tumours. However, its mechanisms of action and how acquired resistance to …

The phosphatase and tensin homolog (PTEN) is a tumor suppressor that is inactivated in
many human cancers. PTEN loss has been associated with resistance to inhibitors of the …

T-Lymphocyte kinases are important checkpoints that control T-cell motility by regulating a
diverse range of signal transduction pathways. The distinct configuration of kinase events in …

Lung cancer is a heterogeneous disease encompassing a wide array of genetic
abnormalities. The MET receptor tyrosine kinase is altered in many lung cancers, especially …

Alzheimer's disease (AD) is characterized by a long pre-clinical phase (20–30 years), during
which significant brain pathology manifests itself. Disease mechanisms associated with …

PURPOSE: Tumor response of rectal cancer to preoperative chemoradiotherapy (CRT)
varies considerably. In experimental tumor models and clinical radiotherapy, activity of …

Peptide microarray technology can be used to identify substrates for recombinant kinases, to
measure kinase activity and changes thereof in cell lysates and lysates from fresh frozen …

Despite the widespread use of kinase-targeted agents in clear cell renal cell carcinoma (CC-
RCC), comprehensive kinase activity evaluation (kinomic profiling) of these tumors is …