Abstract The US Food and Drug Administration has approved a total of 37 new drugs in
2022, which are composed of 20 chemical entities and 17 biologics. In particular, 20 …

Type A γ-aminobutyric acid receptors (GABAARs) are the principal inhibitory receptors in the
brain and the target of a wide range of clinical agents, including anaesthetics, sedatives …

Postpartum depression is a serious disease with a high incidence and severe impact on
pregnant women and infants, but its mechanism remains unclear. Recent studies have …

Lipid nanodiscs have become a standard tool for studying membrane proteins, including
using single particle cryo-electron microscopy (cryo-EM). We find that reconstituting the …

Psychosis is an abnormal mental condition that can cause patients to lose contact with
reality. It is a common symptom of schizophrenia, bipolar disorder, sleep deprivation, and …

Depression is among the most common psychiatric illnesses, which imposes a major
socioeconomic burden on patients, caregivers, and the public health system. Treatment with …

Fipronil, a pesticide widely used to control agricultural and household insect pests, blocks
insect GABA A and glutamate (GluCl) ionotropic receptors, resulting in uncontrolled …

Depression is a major global health issue that urgently requires innovative and precise
treatment options. In this context, saikosaponin has emerged as a promising candidate …

Stroke is the second-leading cause of death and the leading cause of disability in much of
the world. In particular, China faces the greatest challenge from stroke, since the population …

Febrile seizures (FS) are the most common form of epilepsy in children between six months
and five years of age. FS is a self-limited type of fever-related seizure. However, complicated …