CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Cancer is currently ineffectively treated using therapeutic drugs, and is also able to resist
drug action, resulting in increased side effects following drug treatment. A novel therapeutic …

The nucleolus is a prominent subnuclear compartment, where ribosome biosynthesis takes
place. Recently, the nucleolus has gained attention for its novel role in the regulation of …

Cancer is one of the leading causes of death worldwide. Conventional cancer therapies
mainly focus on mass cell killing without high specificity and often cause severe side effects …

Elevated levels of protein kinase CK2 (formerly casein kinase 2 or II) have long been
associated with increased cell growth and proliferation both in normal and cancer cells. The …

CK2 genes are overexpressed in many human cancers, and most often overexpression is
associated with worse prognosis. Site-specific expression in mice leads to cancer …

New peptide-based probes to facilitate the molecular imaging of disease are rapidly
evolving due to implementation of combinatorial chemistry and bacteriophage (phage) …

Following the discovery of the human kinome, protein kinases have become the second
most important group of drug targets as they can be modulated by small ligand molecules …

The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …

Cancer is a serious concern in public health worldwide. Numerous modalities including
surgery, radiotherapy, and chemotherapy, have been used for cancer therapies in clinic …