The future of brain circuit-targeted therapeutics
The principle of targeting brain circuits has drawn increasing attention with the growth of
brain stimulation treatments such as transcranial magnetic stimulation (TMS), deep brain …
brain stimulation treatments such as transcranial magnetic stimulation (TMS), deep brain …
[HTML][HTML] Functional dysconnectivity in youth depression: Systematic review, meta‐analysis, and network-based integration
Youth depression has been associated with heterogenous patterns of aberrant brain
connectivity. To make sense of these divergent findings, we conducted a systematic review …
connectivity. To make sense of these divergent findings, we conducted a systematic review …
[HTML][HTML] TSPO PET brain inflammation imaging: A transdiagnostic systematic review and meta-analysis of 156 case-control studies
Introduction The 18-kDa translocator protein (TSPO) is increasingly recognized as a
molecular target for PET imaging of inflammatory responses in various central nervous …
molecular target for PET imaging of inflammatory responses in various central nervous …
White matter dysfunction in psychiatric disorders is associated with neurotransmitter and genetic profiles
GJ Ji, J Sun, Q Hua, L Zhang, T Zhang, T Bai… - Nature Mental …, 2023 - nature.com
Functional changes of white matter are largely unexplored in patients with psychiatric
disorders. This study examined white matter dysfunctions common in four major psychiatric …
disorders. This study examined white matter dysfunctions common in four major psychiatric …
Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments
One of the most critical challenges in using noninvasive brain stimulation (NIBS) techniques
for the treatment of psychiatric and neurologic disorders is inter-and intra-individual …
for the treatment of psychiatric and neurologic disorders is inter-and intra-individual …
[HTML][HTML] The insula: Leveraging cellular and systems-level research to better understand its roles in health and schizophrenia
Schizophrenia is a highly heterogeneous disorder characterized by a multitude of complex
and seemingly non-overlapping symptoms. The insular cortex has gained increasing …
and seemingly non-overlapping symptoms. The insular cortex has gained increasing …
The return of the lesion for localization and therapy
Historically, pathological brain lesions provided the foundation for localization of symptoms
and therapeutic lesions were used as a treatment for brain diseases. New medications …
and therapeutic lesions were used as a treatment for brain diseases. New medications …
Multiple faces of anxiety: a frontal lobe perspective
AC Roberts, KG Mulvihill - Trends in Neurosciences, 2024 - cell.com
Marked dysregulation of the human prefrontal cortex (PFC) and anterior cingulate cortex
(ACC) characterises a variety of anxiety disorders, and its amelioration is a key feature of …
(ACC) characterises a variety of anxiety disorders, and its amelioration is a key feature of …
Towards interpretable imaging genomics analysis: Methodological developments and applications
X Cen, W Dong, W Lv, Y Zhao, F Dubee, AFA Mentis… - Information …, 2024 - Elsevier
Identifying the relationship between imaging features and genetic variation (a term coined
“imaging genomics”) offers valuable insight into the pathogenesis of cancer, as well as …
“imaging genomics”) offers valuable insight into the pathogenesis of cancer, as well as …
Network localization of state and trait of auditory verbal hallucinations in schizophrenia
F Mo, H Zhao, Y Li, H Cai, Y Song, R Wang… - Schizophrenia …, 2024 - academic.oup.com
Abstract Background and Hypothesis Neuroimaging studies investigating the neural
substrates of auditory verbal hallucinations (AVH) in schizophrenia have yielded mixed …
substrates of auditory verbal hallucinations (AVH) in schizophrenia have yielded mixed …