The future of brain circuit-targeted therapeutics

SH Siddiqi, S Khosravani, JD Rolston… - …, 2024 - nature.com
The principle of targeting brain circuits has drawn increasing attention with the growth of
brain stimulation treatments such as transcranial magnetic stimulation (TMS), deep brain …

[HTML][HTML] Functional dysconnectivity in youth depression: Systematic review, meta‐analysis, and network-based integration

NY Tse, A Ratheesh, S Ganesan, A Zalesky… - Neuroscience & …, 2023 - Elsevier
Youth depression has been associated with heterogenous patterns of aberrant brain
connectivity. To make sense of these divergent findings, we conducted a systematic review …

[HTML][HTML] TSPO PET brain inflammation imaging: A transdiagnostic systematic review and meta-analysis of 156 case-control studies

LJ De Picker, M Morrens, I Branchi… - Brain, Behavior, and …, 2023 - Elsevier
Introduction The 18-kDa translocator protein (TSPO) is increasingly recognized as a
molecular target for PET imaging of inflammatory responses in various central nervous …

White matter dysfunction in psychiatric disorders is associated with neurotransmitter and genetic profiles

GJ Ji, J Sun, Q Hua, L Zhang, T Zhang, T Bai… - Nature Mental …, 2023 - nature.com
Functional changes of white matter are largely unexplored in patients with psychiatric
disorders. This study examined white matter dysfunctions common in four major psychiatric …

Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments

G Soleimani, MA Nitsche, TO Bergmann… - Translational …, 2023 - nature.com
One of the most critical challenges in using noninvasive brain stimulation (NIBS) techniques
for the treatment of psychiatric and neurologic disorders is inter-and intra-individual …

[HTML][HTML] The insula: Leveraging cellular and systems-level research to better understand its roles in health and schizophrenia

AR Kittleson, ND Woodward, S Heckers… - … & Biobehavioral Reviews, 2024 - Elsevier
Schizophrenia is a highly heterogeneous disorder characterized by a multitude of complex
and seemingly non-overlapping symptoms. The insular cortex has gained increasing …

The return of the lesion for localization and therapy

J Joutsa, N Lipsman, A Horn, GR Cosgrove, MD Fox - Brain, 2023 - academic.oup.com
Historically, pathological brain lesions provided the foundation for localization of symptoms
and therapeutic lesions were used as a treatment for brain diseases. New medications …

Multiple faces of anxiety: a frontal lobe perspective

AC Roberts, KG Mulvihill - Trends in Neurosciences, 2024 - cell.com
Marked dysregulation of the human prefrontal cortex (PFC) and anterior cingulate cortex
(ACC) characterises a variety of anxiety disorders, and its amelioration is a key feature of …

Towards interpretable imaging genomics analysis: Methodological developments and applications

X Cen, W Dong, W Lv, Y Zhao, F Dubee, AFA Mentis… - Information …, 2024 - Elsevier
Identifying the relationship between imaging features and genetic variation (a term coined
“imaging genomics”) offers valuable insight into the pathogenesis of cancer, as well as …

Network localization of state and trait of auditory verbal hallucinations in schizophrenia

F Mo, H Zhao, Y Li, H Cai, Y Song, R Wang… - Schizophrenia …, 2024 - academic.oup.com
Abstract Background and Hypothesis Neuroimaging studies investigating the neural
substrates of auditory verbal hallucinations (AVH) in schizophrenia have yielded mixed …