The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …

Hypoxia inducible factor (HIF) is a transcription factor that acts in low-oxygen conditions. The
cellular response to HIF activation is transcriptional upregulation of a large group of genes …

Organoid models of early tissue development have been produced for the intestine, brain,
kidney and other organs, but similar approaches for the heart have been lacking. Here we …

INTRODUCTION The vertebrate heart is composed of diverse cell types, all essential for
normal cardiac function. In the mouse, the earliest mesodermal progenitors of …

Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference
from glucose to fatty acids for postnatal energy production,. This adaptation is triggered in …

Cardiac development arises from two sources of mesoderm progenitors, the first heart field
(FHF) and the second (SHF). Mesp1 has been proposed to mark the most primitive …

The heart is formed from cardiogenic progenitors expressing the transcription factors Nkx2-5
and Isl1 (refs and). These multipotent progenitors give rise to cardiomyocyte, smooth muscle …

Cardiogenesis requires the generation of endothelial, cardiac, and smooth muscle cells,
thought to arise from distinct embryonic precursors. We use genetic fate-mapping studies to …

During the processes leading to adverse cardiac remodeling and heart failure,
cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating …

Left ventricular noncompaction (LVNC) causes prominent ventricular trabeculations and
reduces cardiac systolic function. The clinical presentation of LVNC ranges from …