This review examines the biological significance, therapeutic potential and mechanism (s) of
action of a range of nitric oxide‐releasing non‐steroidal anti‐inflammatory drugs (NO …

Despite many advances in the provision of pain services, acute pain after surgery remains a
serious cause of severe suffering that is often undermanaged despite our best efforts. 6 34 …

Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN)
is the most important mediating mechanism. This mechanism involves direct action of …

Deep somatic pain originating in joints and tendons is a major therapeutic challenge.
Spontaneous pain and mechanical hypersensitivity can develop as a consequence of …

This critical review highlights the advances in developing new molecules for treating pain
syndrome, an important issue for human health. Acetaminophen (APAP, known as …

New generations of cyclooxygenase (COX) inhibitors are more potent and efficacious than
their traditional parent compounds. They are also safer than the classic non‐steroidal anti …

Acetaminophen is one of the most popular and widely used analgesics for the treatment of
pain and fever but few studies have evaluated its effects on neuropathic pain. This study …

Nitric oxide (NO) participates, at least in part, to the establishment and maintenance of pain
after nerve injury. Therefore, drugs that target the NO/cGMP signaling pathway are of interest …

Since the introduction of selective cyclooxygenase-2 inhibitors (coxibs), there has been an
ongoing discussion about the cardiovascular (CV) safety of coxibs and the traditional …

Acetaminophen (APAP) in humans has robust effects with a high therapeutic index in
altering postoperative and inflammatory pain states in clinical and experimental pain …