Pseudomonas aeruginosa is a pathogen often encountered in a healthcare setting. It has
consistently ranked among the most frequent pathogens seen in nosocomial infections …

Introduction The choice of best therapeutic strategy for difficult-to-treat resistance (DTR)
Gram-negative infections currently represents an unmet clinical need. Areas covered This …

Although available data are still limited, real-world evidence regarding mainly ceftolozane-
tazobactam and ceftazidime-avibactam could support the administration of novel beta …

Introduction Several novel beta-lactams (BLs) and/or beta lactams/beta-lactamase inhibitors
(BL/BLIs) have been recently developed for the management of multidrug-resistant bacterial …

Carbapenem resistance in difficult-to-treat P. aeruginosa (DTR-PA) strains is primarily
mediated by loss or reduction of the OprD porin, overexpression of the cephalosporinase …

(1) Background: To develop evidence-based algorithms for targeted antibiotic therapy of
infection-related ventilator-associated complications (IVACs) caused by non-fermenting …

Prompt implementation of appropriate targeted antibiotic therapy represents a valuable
approach in improving clinical and ecological outcome in critically septic patients. This …

The containment of the phenomenon of resistance towards antimicrobials is a priority,
especially in preserving molecules acting against Gram-negative pathogens, which …

Unresolved issues in the identification and treatment of car... : Current Opinion in Infectious
Diseases Unresolved issues in the identification and treatment of carbapenem-resistant …

Outpatient parenteral antimicrobial therapy (OPAT) is a useful treatment strategy against
Pseudomonas aeruginosa and other multidrug-resistant bacteria. However, it is hindered by …