The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-coping resilience to cells, contribute to subcellular and tissue-specific …

Cells respond to mechanical forces by activating specific genes and signaling pathways that
allow the cells to adapt to their physical environment. Examples include muscle growth in …

Mutations in the lamin A/C gene (LMNA), which encodes A-type lamins, cause a diverse
range of diseases collectively called laminopathies, the most common of which is dilated …

Intermediate filament (IF) proteins are critical regulators in health and disease. The
discovery of hundreds of mutations in IF genes and posttranslational modifications has been …

Intermediate filaments are major components of the cytoskeleton. Desmin and synemin,
cytoplasmic intermediate filament proteins and A-type lamins, nuclear intermediate filament …

AIMS We identified an autosomal dominant non-sense mutation (R225X) in exon 4 of the
lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated …

Severe cardiac remodeling leading to heart failure in individuals harboring pathogenic
LMNA variants, known as cardiolaminopathy, poses a significant clinical challenge …

Morphological changes in the size and shape of the nucleus are highly prevalent in cancer,
but the underlying molecular mechanisms and the functional relevance remain poorly …

We previously interrogated the transcriptome in heart tissue from Lmna H222P/H222P mice,
a mouse model of cardiomyopathy caused by lamin A/C gene (LMNA) mutation, and found …