[HTML][HTML] The skin barrier: an extraordinary interface with an exceptional lipid organization

JA Bouwstra, A Nădăban, W Bras, C McCabe… - Progress in lipid …, 2023 - Elsevier
The barrier function of the skin is primarily located in the stratum corneum (SC), the
outermost layer of the skin. The SC is composed of dead cells with highly organized lipid …

Using molecular simulation to understand the skin barrier

P Shamaprasad, CO Frame, TC Moore, A Yang… - Progress in lipid …, 2022 - Elsevier
Skin's effectiveness as a barrier to permeation of water and other chemicals rests almost
entirely in the outermost layer of the epidermis, the stratum corneum (SC), which consists of …

Contribution of galactoglycerolipids to the 3‐dimensional architecture of thylakoids

B Demé, C Cataye, MA Block, E Maréchal… - The FASEB …, 2014 - Wiley Online Library
Thylakoid membranes, the universal structure where photosynthesis takes place in all
oxygenic photosynthetic organisms from cyanobacteria to higher plants, have a unique lipid …

Understanding the structure and dynamics of complex biomembrane interactions by neutron scattering techniques

S Qian, VK Sharma, LA Clifton - Langmuir, 2020 - ACS Publications
The membrane is one of the key structural materials of biology at the cellular level.
Composed predominantly of a bilayer of lipids with embedded and bound proteins, it defines …

[HTML][HTML] Stratum corneum lipid matrix: Location of acyl ceramide and cholesterol in the unit cell of the long periodicity phase

EH Mojumdar, GS Gooris, D Groen, DJ Barlow… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The extracellular lipid matrix in the skin's outermost layer, the stratum corneum, is crucial for
the skin barrier. The matrix is composed of ceramides (CERs), cholesterol (CHOL) and free …

Molecular dynamics simulation study of permeation of molecules through skin lipid bilayer

R Gupta, DB Sridhar, B Rai - The Journal of Physical Chemistry B, 2016 - ACS Publications
Stratum Corneum (SC), the outermost layer of skin, is mainly responsible for skin's barrier
function. The complex lipid matrix of SC determines these barrier properties. In this study …

[HTML][HTML] The role of ceramide chain length distribution on the barrier properties of the skin lipid membranes

EH Mojumdar, Z Kariman, L Van Kerckhove… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are
composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids …

The intriguing molecular dynamics of Cer [EOS] in rigid skin barrier lipid layers requires improvement of the model

F Fandrei, T Havrišák, L Opálka, O Engberg… - Journal of Lipid …, 2023 - ASBMB
Omega-O-acyl ceramides such as 32-linoleoyloxydotriacontanoyl sphingosine (Cer [EOS])
are essential components of the lipid skin barrier, which protects our body from excessive …

Phytosphingosine ceramide mainly localizes in the central layer of the unique lamellar phase of skin lipid model systems

A Nădăban, GS Gooris, CM Beddoes… - Journal of Lipid …, 2022 - ASBMB
Understanding the lipid arrangement within the skin's outermost layer, the stratum corneum
(SC), is important for advancing knowledge on the skin barrier function. The SC lipid matrix …

Barrier capability of skin lipid models: effect of ceramides and free fatty acid composition

LE Uche, GS Gooris, JA Bouwstra, CM Beddoes - Langmuir, 2019 - ACS Publications
The skin is an effective barrier that prevents the influx of harmful substances from the
environment and the efflux of body fluid. This barrier function is ascribed to the intercellular …