The role of adipokines in health and disease

VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Adipokines are cell-signaling proteins secreted by adipose tissue that has been related to a
low-grade state of inflammation and different pathologies. The present review aims to …

[HTML][HTML] A systematic review of licensed weight-loss medications in treating antipsychotic-induced weight gain and obesity in schizophrenia and psychosis

K Lee, S Abraham, R Cleaver - General Hospital Psychiatry, 2022 - Elsevier
Background Schizophrenia and antipsychotic use are associated with clinically significant
weight gain and subsequent increased mortality. Despite weight loss medications (WLMs) …

GPCRs in intracellular compartments: New targets for drug discovery

I Fasciani, M Carli, F Petragnano, F Colaianni, G Aloisi… - Biomolecules, 2022 - mdpi.com
The architecture of eukaryotic cells is defined by extensive membrane-delimited
compartments, which entails separate metabolic processes that would otherwise interfere …

Current status of therapeutic drug monitoring in mental health treatment: A review

F Pennazio, C Brasso, V Villari, P Rocca - Pharmaceutics, 2022 - mdpi.com
Therapeutic drug monitoring (TDM) receives growing interest in different psychiatric clinical
settings (emergency, inpatient, and outpatient services). Despite its usefulness, TDM …

Crosstalk between schizophrenia and metabolic syndrome: The role of oxytocinergic dysfunction

KK Goh, CYA Chen, TH Wu, CH Chen… - International journal of …, 2022 - mdpi.com
The high prevalence of metabolic syndrome in persons with schizophrenia has spurred
investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis …

Polypharmacology: promises and new drugs in 2022

P Ryszkiewicz, B Malinowska, E Schlicker - Pharmacological Reports, 2023 - Springer
Polypharmacology is an emerging strategy of design, synthesis, and clinical implementation
of pharmaceutical agents that act on multiple targets simultaneously. It should not be mixed …

A Novel Gliotransmitter, L-β-Aminoisobutyric Acid, Contributes to Pathophysiology of Clinical Efficacies and Adverse Reactions of Clozapine

K Fukuyama, E Motomura, M Okada - Biomolecules, 2023 - mdpi.com
Clozapine is listed as one of the most effective antipsychotics and has been approved for
treating treatment-resistant schizophrenia (TRS); however, several type A and B adverse …

Shared genetics of psychiatric disorders and type 2 diabetes: a large-scale genome-wide cross-trait analysis

H Ding, M Xie, J Wang, M Ouyang, Y Huang… - Journal of Psychiatric …, 2023 - Elsevier
Background Individuals with psychiatric disorders have elevated rates of type 2 diabetes
comorbidity. Although little is known about the shared genetics and causality of this …

Hallucinations and delusions associated with Parkinson's disease psychosis: safety of current treatments and future directions

SH Isaacson, L Citrome - Expert Opinion on Drug Safety, 2022 - Taylor & Francis
ABSTRACT Introduction Over half of Parkinson's disease (PD) patients develop psychotic
symptoms, and PD psychosis (PDP) is associated with significant distress to patients …

Antipsychotic drug—Aripiprazole against schizophrenia, its therapeutic and metabolic effects associated with gene polymorphisms

A Stelmach, K Guzek, A Rożnowska, I Najbar… - Pharmacological …, 2023 - Springer
Second-generation antipsychotics are widely used for the treatment of schizophrenia.
Aripiprazole (ARI) is classified as a third-generation antipsychotic drug with a high affinity for …