Mass spectrometry (MS) has emerged at the forefront of quantitative proteomic techniques.
Liquid chromatography‐mass spectrometry (LC‐MS) can be used to determine abundances …

Top-down protein mass spectrometry can provide unique insights into protein sequence and
structure, including precise proteoform identification and study of protein–ligand and protein …

Unraveling the complexity of biological systems relies on the development of new
approaches for spatially resolved proteoform‐specific analysis of the proteome. Herein, we …

Existing mass spectrometric assays used for sensitive and specific measurements of target
proteins across multiple samples, such as selected/multiple reaction monitoring (SRM/MRM) …

While identification-centric (qualitative) top-down proteomics (TDP) has seen rapid progress
in the recent past, the quantification of intact proteoforms within complex proteomes is still …

Isobaric chemical tag labels (eg, iTRAQ and TMT) have been extensively utilized as a
standard quantification approach in bottom-up proteomics, which provides high multiplexing …

Microproteins and short open reading frame-encoded peptides (SEPs) can, like all proteins,
carry numerous posttranslational modifications. Together with posttranscriptional processes …

Isobaric chemical tag labeling (eg, TMT) is a commonly used approach in quantitative
proteomics, and quantification is enabled through detection of low-mass reporter ions …

Biological processes unfold across broad spatial and temporal dimensions, and
measurement of the underlying molecular world is essential to their understanding …

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors in
humans. They mediate nearly all aspects of human physiology and thus are of high …