Recently, much attention has been given to the problem of drug delivery through the cell‐
membrane in order to treat and manage several diseases. The discovery of cell penetrating …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Regulatory T cells prevent the emergence of autoantibodies and excessive IgE, but the
precise mechanisms are unclear. Here, we show that BCL6-expressing Tregs, known as …

Since the first description of their opioid properties three decades ago, dynorphins have
increasingly been thought to play a regulatory role in numerous functional pathways of the …

There is now substantial evidence that compounds released during host stress directly
activate the virulence of certain opportunistic pathogens. Here, we considered that …

Spinocerebellar ataxias (SCAs) are dominantly inherited neurodegenerative disorders
characterized by progressive cerebellar ataxia and dysarthria. We have identified missense …

Opioid addiction and overdose are at record levels in the United States. This is driven, in
part, by their widespread prescription for the treatment of pain, which also increased …

Mass spectrometry (MS), with its immense technological developments over the last two
decades, has emerged as an unavoidable technique in analyzing biomolecules such as …

Acute activation of kappa-opioid receptors produces anti-addictive effects by regulating
dopamine levels in the brain. Unfortunately, classic kappa-opioid agonists have undesired …

Ample evidence exists showing that eukaryotic signal molecules synthesized and released
by the host can activate the virulence of opportunistic pathogens. The sensitivity of …