Eleven grand challenges in single-cell data science
The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …
[HTML][HTML] Biomarkers of gastric cancer: Current topics and future perspective
T Matsuoka, M Yashiro - World journal of gastroenterology, 2018 - ncbi.nlm.nih.gov
Gastric cancer (GC) is one of the most prevalent malignant types in the world and an
aggressive disease with a poor 5-year survival. This cancer is biologically and genetically …
aggressive disease with a poor 5-year survival. This cancer is biologically and genetically …
Single-cell genome sequencing: current state of the science
The field of single-cell genomics is advancing rapidly and is generating many new insights
into complex biological systems, ranging from the diversity of microbial ecosystems to the …
into complex biological systems, ranging from the diversity of microbial ecosystems to the …
Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network
BACKGROUND Elucidating the genetic architecture of neuropsychiatric disorders remains a
major scientific and medical challenge. Emerging genomic technologies now permit the …
major scientific and medical challenge. Emerging genomic technologies now permit the …
EBV-associated diseases: Current therapeutics and emerging technologies
EBV is a prevalent virus, infecting> 90% of the world's population. This is an oncogenic virus
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …
Methods to improve the accuracy of next-generation sequencing
C Cheng, Z Fei, P Xiao - Frontiers in bioengineering and …, 2023 - frontiersin.org
Next-generation sequencing (NGS) is present in all fields of life science, which has greatly
promoted the development of basic research while being gradually applied in clinical …
promoted the development of basic research while being gradually applied in clinical …
Separation and parallel sequencing of the genomes and transcriptomes of single cells using G&T-seq
Parallel sequencing of a single cell's genome and transcriptome provides a powerful tool for
dissecting genetic variation and its relationship with gene expression. Here we present a …
dissecting genetic variation and its relationship with gene expression. Here we present a …
Advances and applications of single‐cell omics technologies in plant research
Y Mo, Y Jiao - The Plant Journal, 2022 - Wiley Online Library
Single‐cell sequencing approaches reveal the intracellular dynamics of individual cells and
answer biological questions with high‐dimensional catalogs of millions of cells, including …
answer biological questions with high‐dimensional catalogs of millions of cells, including …
Detecting somatic mutations in normal cells
Somatic mutations have been studied extensively in the context of cancer. Recent studies
have demonstrated that high-throughput sequencing data can be used to detect somatic …
have demonstrated that high-throughput sequencing data can be used to detect somatic …
Tumor heterogeneity, single-cell sequencing, and drug resistance
F Schmidt, T Efferth - Pharmaceuticals, 2016 - mdpi.com
Tumor heterogeneity has been compared with Darwinian evolution and survival of the fittest.
The evolutionary ecosystem of tumors consisting of heterogeneous tumor cell populations …
The evolutionary ecosystem of tumors consisting of heterogeneous tumor cell populations …