About a fifth of all human cancers worldwide are caused by infectious agents. In 12% of
cancers, seven different viruses have been causally linked to human oncogenesis: Epstein …

The annexins are a family of proteins that bind acidic phospholipids in the presence of Ca
2+. The interaction of these proteins with biological membranes has led to the suggestion …

We recently described the purification and cloning of extracellular signal-regulated kinase 1
(ERKl), which appears to play a pivotal role In converting tyrosine phosphorylation into the …

A protein kinase characterized by its ability to phosphorylate microtubule-associated protein-
2 (MAP2) and myelin basic protein (MBP) is thought to play a pivotal role in the transduction …

pp42, a low-abundance 42-kDa protein, becomes transiently phosphorylated on tyrosine
after stimulation of fibroblasts by a variety of mitogens, including epidermal growth factor …

Figure 1. Activation ofa protein kinase cascade through the insulin signaling pathway.
Exposing cells to insulin (+) causes autophosphorylation of the, B subunit of the insulin …

Publisher Summary This chapter discusses the detection and quantification of
phosphotyrosine in proteins. Protein kinases can be differentiated according to their amino …

Isozymes of enolase, phosphoglycerate mutase and lactate dehydrogenase are
phosphorylated at tyrosine in cells transformed by viruses whose transforming proteins are …

The function of the Xenopus laevis ribosomal spacer has been studied in vivo and by
microinjection of in vitro mutants into Xenopus oocytes. It is shown that the spacer directs …

We examine the interaction between polyoma-virusencoded middle tumor antigen and the
cellular src gene product, ppSV”, using a series of monoclonal antibodies that recognize …