Thieno [2, 3-d] pyrimidine as a promising scaffold in medicinal chemistry: Recent advances
EMH Ali, MS Abdel-Maksoud, CH Oh - Bioorganic & medicinal chemistry, 2019 - Elsevier
Thienopyrimidine scaffold is a fused heterocyclic ring system that structurally can be
considered as adenine, the purine base that is found in both DNA and RNA-bioisosteres …
considered as adenine, the purine base that is found in both DNA and RNA-bioisosteres …
Recent developments regarding the use of thieno [2, 3-d] pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties
K Bozorov, JY Zhao, B Elmuradov, A Pataer… - European Journal of …, 2015 - Elsevier
It is generally understood that the antitumor properties of synthetic heterocyclic compounds
are among the most powerful properties that can be made use in medicinal chemistry. More …
are among the most powerful properties that can be made use in medicinal chemistry. More …
Synthesis of 4-substituted pyrido [2, 3-d] pyrimidin-4 (1H)-one as analgesic and anti-inflammatory agents
ARBA El-Gazzar, HN Hafez - Bioorganic & medicinal chemistry letters, 2009 - Elsevier
4-Substituted-pyrido [2, 3-d] pyrimidin-4 (1H)-ones 4a–c were synthesized by oxidation of 4-
substituted-dihydropyrido [2, 3-d] pyrimidin-4 (1H)-ones 3a–c which were in turn prepared …
substituted-dihydropyrido [2, 3-d] pyrimidin-4 (1H)-ones 3a–c which were in turn prepared …
[PDF][PDF] Combined 3D-QSAR and molecular docking analysis of thienopyrimidine derivatives as Staphylococcus aureus inhibitors
The discovery of antibacterials is considered one of the greatest medical achievements of all
time. In this work, a combination of three computational analyzes: 3D-QSAR, molecular …
time. In this work, a combination of three computational analyzes: 3D-QSAR, molecular …
Design, synthesis and biological evaluation of novel thieno [3, 2-d] pyrimidine derivatives possessing diaryl semicarbazone scaffolds as potent antitumor agents
Z Liu, S Wu, Y Wang, R Li, J Wang, L Wang… - European journal of …, 2014 - Elsevier
A series of novel thieno [3, 2-d] pyrimidine derivatives possessing diaryl semicarbazone
scaffolds were designed, synthesized and evaluated for their anticancer activity. Most …
scaffolds were designed, synthesized and evaluated for their anticancer activity. Most …
A facile method for preparation and evaluation of the antimicrobial efficiency of various heterocycles containing thieno[2,3-d]pyrimidine
Heterocyclic compounds play an important role in the field of pharmaceutical chemistry,
especially compounds containing hybrid bioactive moieties. So in continuation of our work …
especially compounds containing hybrid bioactive moieties. So in continuation of our work …
Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors
A group of EGFR inhibitors derived from thieno [2, 3-d] pyrimidine nucleus was designed,
synthesised, and examined as anti-proliferative lead compounds. MCF-7 and A549 cell lines …
synthesised, and examined as anti-proliferative lead compounds. MCF-7 and A549 cell lines …
Synthesis and antitumor activity of substituted triazolo [4, 3-a] pyrimidin-6-sulfonamide with an incorporated thiazolidinone moiety
HN Hafez, ARBA El-Gazzar - Bioorganic & medicinal chemistry letters, 2009 - Elsevier
Chlorosulfonation of 3-methyl [1, 2, 4] triazolo [4, 3-a] pyrimidine with chlorosulfonic acid in
the presence of thionyl chloride was studied. When triazolo [4, 3-a] pyrimidines are used as …
the presence of thionyl chloride was studied. When triazolo [4, 3-a] pyrimidines are used as …
Synthesis of substituted thieno [2, 3-d] pyrimidine-2, 4-dithiones and their S-glycoside analogues as potential antiviral and antibacterial agents
HN Hafez, HAR Hussein, ARBA El-Gazzar - European Journal of medicinal …, 2010 - Elsevier
Previously, we synthesized and evaluated several thienopyrimidine derivatives containing
heterocyclic ring substituents linked to the pyrimidine-2-thione nucleus at C-2 by a two-to …
heterocyclic ring substituents linked to the pyrimidine-2-thione nucleus at C-2 by a two-to …
Carbonic anhydrase inhibitors: synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel …
A series of novel pyrroles, pyrrolopyrimidines, pyrazolopyrrolopyrimidine,
triazolopyrrolopyrimidines, tetrazolopyrrolopyrimidine, triazinopyrrolopyrimidines and …
triazolopyrrolopyrimidines, tetrazolopyrrolopyrimidine, triazinopyrrolopyrimidines and …