The role of myofibroblasts in physiological and pathological tissue repair

R Schuster, F Younesi, M Ezzo… - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Neutrophils in tissue trauma of the skin, bone, and lung: two sides of the same coin

A Kovtun, DAC Messerer… - Journal of …, 2018 - Wiley Online Library
Following severe tissue injury, patients are exposed to various danger‐and microbe‐
associated molecular patterns, which provoke a strong activation of the neutrophil defense …

Scarless wound healing: from development to senescence

H Pratsinis, E Mavrogonatou, D Kletsas - Advanced drug delivery reviews, 2019 - Elsevier
An essential element of tissue homeostasis is the response to injuries, cutaneous wound
healing being the most studied example. In the adults, wound healing aims at quickly …

Anti-fibrotic effects of statin drugs: A review of evidence and mechanisms

DM Dolivo, CR Reed, KA Gargiulo… - Biochemical …, 2023 - Elsevier
Fibrosis is a pathological repair process common among organs, that responds to tissue
damage by replacement with non-functional connective tissue. Despite the widespread …

Therapeutic strategies to reduce burn wound conversion

A Palackic, JW Jay, RP Duggan, LK Branski, SE Wolf… - Medicina, 2022 - mdpi.com
Burn wound conversion refers to the phenomenon whereby superficial burns that appear to
retain the ability to spontaneously heal, convert later into deeper wounds in need of …

Advances in immunomodulation and immune engineering approaches to improve healing of extremity wounds

PJ Muire, MA Thompson, RJ Christy… - International Journal of …, 2022 - mdpi.com
Delayed healing of traumatic wounds often stems from a dysregulated immune response
initiated or exacerbated by existing comorbidities, multiple tissue injury or wound …

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Z Liu, Y Li, W Li, W Lian, M Kemell, S Hietala… - Materials …, 2019 - pubs.rsc.org
Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The
microfluidics-produced nanohybrids endow the system with an orchestrated cascade from …

The role of the inflammatory response in burn injury

XL Strudwick, AJ Cowin - Hot topics in burn injuries. Adelaide …, 2018 - books.google.com
Burns are characterised by significant local swelling and redness around the site of injury,
indicative of acute inflammation. Whilst the inflammatory response is fundamental to the …

Pharmacotherapy for keloids and hypertrophic scars

T Murakami, S Shigeki - International Journal of Molecular Sciences, 2024 - mdpi.com
Keloids (KD) and hypertrophic scars (HTS), which are quite raised and pigmented and have
increased vascularization and cellularity, are formed due to the impaired healing process of …

Balance and circumstance: the renin angiotensin system in wound healing and fibrosis

R Bernasconi, A Nyström - Cellular signalling, 2018 - Elsevier
The tissue renin angiotensin system (tRAS) is a locally-acting master-modulator of tissue
homeostasis and regeneration. Through these abilities, it is emerging as an attractive target …