The cell-cell adhesion molecule E-cadherin
F Van Roy, G Berx - Cellular and molecular life sciences, 2008 - Springer
This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …
Structure and biochemistry of cadherins and catenins
Classical cadherins mediate specific adhesion at intercellular adherens junctions.
Interactions between cadherin ectodomains from apposed cells mediate cell–cell contact …
Interactions between cadherin ectodomains from apposed cells mediate cell–cell contact …
Roles for E-cadherin cell surface regulation in cancer
YI Petrova, L Schecterson… - Molecular biology of the …, 2016 - Am Soc Cell Biol
The loss of E-cadherin expression in association with the epithelial–mesenchymal transition
(EMT) occurs frequently during tumor metastasis. However, metastases often retain E …
(EMT) occurs frequently during tumor metastasis. However, metastases often retain E …
Thinking outside the cell: how cadherins drive adhesion
Cadherins are a superfamily of cell surface glycoproteins whose ectodomains contain
multiple repeats of β-sandwich extracellular cadherin (EC) domains that adopt a similar fold …
multiple repeats of β-sandwich extracellular cadherin (EC) domains that adopt a similar fold …
Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions
Y Wu, P Kanchanawong, R Zaidel-Bar - Developmental cell, 2015 - cell.com
E-cadherin is the major adhesion receptor in epithelial adherens junctions, which connect
cells to form tissues and are essential for morphogenesis and homeostasis. The mechanism …
cells to form tissues and are essential for morphogenesis and homeostasis. The mechanism …
Structure and mechanism of cadherins and catenins in cell-cell contacts
S Pokutta, WI Weis - Annu. Rev. Cell Dev. Biol., 2007 - annualreviews.org
Cadherins are Ca2+-dependent cell adhesion molecules found in several kinds of cell-cell
contact, including adherens junctions and desmosomes. In the presence of Ca2+, cells …
contact, including adherens junctions and desmosomes. In the presence of Ca2+, cells …
Two-step adhesive binding by classical cadherins
Crystal structures of classical cadherins have revealed two dimeric configurations. In the
first, N-terminal β-strands of EC1 domains' swap'between partner molecules. The second …
first, N-terminal β-strands of EC1 domains' swap'between partner molecules. The second …
Mechanism and dynamics of cadherin adhesion
D Leckband, A Prakasam - Annu. Rev. Biomed. Eng., 2006 - annualreviews.org
Cadherins are essential cell adhesion molecules involved in tissue morphogenesis and the
maintenance of tissue architecture in adults. The adhesion and selectivity functions of …
maintenance of tissue architecture in adults. The adhesion and selectivity functions of …
T-cadherin structures reveal a novel adhesive binding mechanism
C Ciatto, F Bahna, N Zampieri… - Nature structural & …, 2010 - nature.com
Vertebrate genomes encode 19 classical cadherins and about 100 nonclassical cadherins.
Adhesion by classical cadherins depends on binding interactions in their N-terminal EC1 …
Adhesion by classical cadherins depends on binding interactions in their N-terminal EC1 …
Dynamics and regulation of epithelial adherens junctions: recent discoveries and controversies
AI Ivanov, NG Naydenov - International review of cell and molecular …, 2013 - Elsevier
Adherens junctions (AJs) are evolutionarily conserved plasma-membrane structures that
mediate cell–cell adhesions in multicellular organisms. They are organized by several types …
mediate cell–cell adhesions in multicellular organisms. They are organized by several types …