Despite the tremendous hurdles presented by the complexity of the liver's structure and
function, advances in liver physiology, stem cell biology and reprogramming, and the …

The liver, the largest organ in the human body, is a multi-functional organ with diverse
metabolic activities that plays a critical role in maintaining the body and sustaining life …

We report the generation of human ESC-derived, expandable hepatic organoids (hEHOs)
using our newly established method with wholly defined (serum-free, feeder free) media …

We have developed a size-controllable spheroidal hepatosphere and heterosphere model
by mono-culturing of primary hepatocytes and by co-culturing primary hepatocytes and …

Tissue injury triggers complex communication between cells via secreted signaling
molecules such as cytokines and growth factors. Discerning when and where these signals …

A major challenge in tissue engineering is to develop robust protocols for differentiating ES
and iPS cells to functional adult tissues at a clinically relevant scale. The goal of this study is …

Bone Morphogenetic Proteins (BMPs) belong to the Transforming Growth Factor-β (TGF-β)
family. Initially identified due to their ability to induce bone formation, they are now known to …

In the liver, hepatocytes are exposed to a large array of stimuli that shape hepatic
phenotype. This in vivo microenvironment is lost when hepatocytes are cultured in standard …

We developed a cell-culture/biosensor platform consisting of aptamer-modified Au
electrodes integrated with reconfigurable microfluidics for monitoring of transforming growth …

Liver fibrosis is the result of the entire organism responding to a chronic injury. Every cell
type in the liver contributes to the fibrosis. This paper first discusses key intracellular …