Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person

L Koklesova, A Mazurakova, M Samec, K Biringer… - EPMA Journal, 2021 - Springer
Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …

Epigenetic modifications in cancer

R Kanwal, S Gupta - Clinical genetics, 2012 - Wiley Online Library
Kanwal R, Gupta S. Epigenetic modifications in cancer. Cancer initiation and progression is
controlled by both genetic and epigenetic events. The complexity of carcinogenesis cannot …

Cancer biology and NuRD: a multifaceted chromatin remodelling complex

AY Lai, PA Wade - Nature Reviews Cancer, 2011 - nature.com
The nucleosome remodelling and histone deacetylase (NuRD; also known as Mi-2) complex
regulates gene expression at the level of chromatin. The NuRD complex has been identified …

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

C Dong, Y Wu, J Yao, Y Wang, Y Yu… - The Journal of …, 2012 - Am Soc Clin Investig
Breast cancers are highly heterogeneous but can be grouped into subtypes based on
several criteria, including level of expression of certain markers. Claudin-low breast cancer …

Cancer epigenetics: an introduction

R Kanwal, K Gupta, S Gupta - Cancer Epigenetics: Risk Assessment …, 2015 - Springer
Epigenetic and genetic alterations contribute to cancer initiation and progression.
Epigenetics refers to the study of heritable changes in gene expression without alterations in …

Cancer chemoprevention by dietary polyphenols: promising role for epigenetics

A Link, F Balaguer, A Goel - Biochemical pharmacology, 2010 - Elsevier
Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but
play an important role in the control of gene expression. In mammals, epigenetic …

Concise drug review: azacitidine and decitabine

EJB Derissen, JH Beijnen, JHM Schellens - The oncologist, 2013 - academic.oup.com
The introduction of the hypomethylating agents azacitidine and decitabine has been a major
advancement in the treatment of patients with higher‐risk myelodysplastic syndromes …

Targeting DNA methylation

JPJ Issa, HM Kantarjian - Clinical Cancer Research, 2009 - AACR
Two nucleoside inhibitors of DNA methylation, azacitidine and decitabine, are now standard
of care for the treatment of the myelodysplastic syndrome, a deadly form of leukemia. These …

Epigenetic mechanisms in inflammation

D Bayarsaihan - Journal of dental research, 2011 - journals.sagepub.com
Epigenetic modifications occur in response to environmental changes and play a
fundamental role in gene expression following environmental stimuli. Major epigenetic …

Meeting the challenge of targeting cancer stem cells

A Turdo, V Veschi, M Gaggianesi, A Chinnici… - Frontiers in cell and …, 2019 - frontiersin.org
Notwithstanding cancer patients benefit from a plethora of therapeutic alternatives, drug
resistance remains a critical hurdle. Indeed, the high mortality rate is associated with …