Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person
L Koklesova, A Mazurakova, M Samec, K Biringer… - EPMA Journal, 2021 - Springer
Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …
Epigenetic modifications in cancer
Kanwal R, Gupta S. Epigenetic modifications in cancer. Cancer initiation and progression is
controlled by both genetic and epigenetic events. The complexity of carcinogenesis cannot …
controlled by both genetic and epigenetic events. The complexity of carcinogenesis cannot …
Cancer biology and NuRD: a multifaceted chromatin remodelling complex
AY Lai, PA Wade - Nature Reviews Cancer, 2011 - nature.com
The nucleosome remodelling and histone deacetylase (NuRD; also known as Mi-2) complex
regulates gene expression at the level of chromatin. The NuRD complex has been identified …
regulates gene expression at the level of chromatin. The NuRD complex has been identified …
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer
C Dong, Y Wu, J Yao, Y Wang, Y Yu… - The Journal of …, 2012 - Am Soc Clin Investig
Breast cancers are highly heterogeneous but can be grouped into subtypes based on
several criteria, including level of expression of certain markers. Claudin-low breast cancer …
several criteria, including level of expression of certain markers. Claudin-low breast cancer …
Cancer epigenetics: an introduction
Epigenetic and genetic alterations contribute to cancer initiation and progression.
Epigenetics refers to the study of heritable changes in gene expression without alterations in …
Epigenetics refers to the study of heritable changes in gene expression without alterations in …
Cancer chemoprevention by dietary polyphenols: promising role for epigenetics
Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but
play an important role in the control of gene expression. In mammals, epigenetic …
play an important role in the control of gene expression. In mammals, epigenetic …
Concise drug review: azacitidine and decitabine
EJB Derissen, JH Beijnen, JHM Schellens - The oncologist, 2013 - academic.oup.com
The introduction of the hypomethylating agents azacitidine and decitabine has been a major
advancement in the treatment of patients with higher‐risk myelodysplastic syndromes …
advancement in the treatment of patients with higher‐risk myelodysplastic syndromes …
Targeting DNA methylation
JPJ Issa, HM Kantarjian - Clinical Cancer Research, 2009 - AACR
Two nucleoside inhibitors of DNA methylation, azacitidine and decitabine, are now standard
of care for the treatment of the myelodysplastic syndrome, a deadly form of leukemia. These …
of care for the treatment of the myelodysplastic syndrome, a deadly form of leukemia. These …
Epigenetic mechanisms in inflammation
D Bayarsaihan - Journal of dental research, 2011 - journals.sagepub.com
Epigenetic modifications occur in response to environmental changes and play a
fundamental role in gene expression following environmental stimuli. Major epigenetic …
fundamental role in gene expression following environmental stimuli. Major epigenetic …
Meeting the challenge of targeting cancer stem cells
Notwithstanding cancer patients benefit from a plethora of therapeutic alternatives, drug
resistance remains a critical hurdle. Indeed, the high mortality rate is associated with …
resistance remains a critical hurdle. Indeed, the high mortality rate is associated with …