There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

Investigations of patients with systemic lupus erythematosus have applied insights from
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …

Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome
whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled …

Motivation In the continuously expanding omics era, novel computational and statistical
strategies are needed for data integration and identification of biomarkers and molecular …

Differences in immune function and responses contribute to health-and life-span disparities
between sexes. However, the role of sex in immune system aging is not well understood …

Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy.
Previously, we demonstrated a potent IFN immunogenicity of nucleic acid–containing (NA …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular …

Neutrophil extracellular traps (NETs) are structures consisting of chromatin and antimicrobial
molecules that are released by neutrophils during a form of regulated cell death called …

Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting synovial joints.
Neutrophils are believed to play an important role in both the initiation and progression of …

SOMAscan is an aptamer-based proteomics assay capable of measuring 1,305 human
protein analytes in serum, plasma, and other biological matrices with high sensitivity and …