Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

Fas-mediated apoptosis contributes to physiological and pathological cellular processes,
such as differentiation and survival. In particular, the roles of Fas in immune cells are …

Abstract CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of
an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the …

Fas (also called CD95 or APO-1), a member of a subgroup of the tumour necrosis factor
receptor superfamily that contain an intracellular death domain, can initiate apoptosis …

During the course of an immune response, antigen-reactive T cells clonally expand and then
are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is …

The proinflammatory cytokine tumor necrosis factor (TNF) α signals both cell survival and
death. The biological outcome of TNFα treatment is determined by the balance between NF …

Interactions between the immune system and malignant cells play an important role in
tumorigenesis. Failure of the immune system to detect and reject transformed cells may lead …

Activation of the caspase cascade is a pivotal step in apoptosis and can occur via death
adaptor‐mediated homo‐oligomerization of initiator procaspases. Here we show that c‐FLIP …

Upon stimulation, CD95 (APO-1/Fas) recruits the adapter molecule FADD/MORT1,
procaspase-8, and the cellular FLICE-inhibitory proteins (c-FLIP) into the death-inducing …

Cell death is executed along several pathways. Apart from necrotic cell death occurring
upon tissue injury, several distinct types of apoptosis have been observed. Apoptosis, or …