Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important
thiol reducing agent involved in the modulation of redox processes. It has also been …

The comet assay is the method of choice for measuring DNA damage, of various sorts, in
human cells such as lymphocytes obtained in the course of population-based studies of …

The complex antioxidant network of plant and animal cells has the thiol tripeptide GSH at its
centre to buffer ROS (reactive oxygen species) and facilitate cellular redox signalling which …

Enzyme screens with Strep-tagged recombinant proteins and expression studies with the
respective green fluorescent protein (GFP) fusions have been employed to examine the …

Glutathione (GSH) is essential for survival of eukaryotic but not in prokaryotic cells. Its
functions in nucleated cells are far from being known. In fact GSH plays an important role in …

За последние 10-15 лет значительно углубились исследования системы глутатиона во
всех основных направлениях. Открыт ряд новых ферментов метаболизма. Многие из …

Abstract Glutathione-S-transferases (GSTs) are phase II detoxification isozymes that
conjugate glutathione (GSH) to xenobiotics and also suppress redox stress. It was …

Background Glutathione is considered essential for survival in mammalian cells and yeast
but not in prokaryotic cells. The presence of a nuclear pool of glutathione has been …

Acquired drug resistance was found to be suppressed in the doxorubicin-resistant breast
cancer cell line MCF7/Dx after pre-treatment with GSNO (nitrosoglutathione). The effect was …

Reactive oxygen species have been described to modulate proteins within the cell, a
process called redox regulation. However, the importance of compartment-specific redox …