The search for noise-induced cochlear synaptopathy in humans: Mission impossible?

N Bramhall, EF Beach, B Epp, CG Le Prell… - Hearing research, 2019 - Elsevier
Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …

Pathophysiology of subjective tinnitus: triggers and maintenance

HF Haider, T Bojić, SF Ribeiro, J Paço… - Frontiers in …, 2018 - frontiersin.org
Tinnitus is the conscious perception of a sound without a corresponding external acoustic
stimulus, usually described as a phantom perception. One of the major challenges for …

Evidence of cochlear neural degeneration in normal-hearing subjects with tinnitus

V Vasilkov, B Caswell-Midwinter, Y Zhao… - Scientific Reports, 2023 - nature.com
Tinnitus, reduced sound-level tolerance, and difficulties hearing in noisy environments are
the most common complaints associated with sensorineural hearing loss in adult …

The neural bases of tinnitus: lessons from deafness and cochlear implants

M Knipper, P Van Dijk, H Schulze… - Journal of …, 2020 - Soc Neuroscience
Subjective tinnitus is the conscious perception of sound in the absence of any acoustic
source. The literature suggests various tinnitus mechanisms, most of which invoke changes …

[HTML][HTML] Tinnitus with a normal audiogram: Relation to noise exposure but no evidence for cochlear synaptopathy

H Guest, KJ Munro, G Prendergast, S Howe, CJ Plack - Hearing research, 2017 - Elsevier
In rodents, exposure to high-level noise can destroy synapses between inner hair cells and
auditory nerve fibers, without causing hair cell loss or permanent threshold elevation. Such …

[HTML][HTML] Evidence of “hidden hearing loss” following noise exposures that produce robust TTS and ABR wave-I amplitude reductions

E Lobarinas, C Spankovich, CG Le Prell - Hearing research, 2017 - Elsevier
In animals, noise exposures that produce robust temporary threshold shifts (TTS) can
produce immediate damage to afferent synapses and long-term degeneration of low …

Weak middle-ear-muscle reflex in humans with noise-induced tinnitus and normal hearing may reflect cochlear synaptopathy

M Wojtczak, JA Beim, AJ Oxenham - ENeuro, 2017 - eneuro.org
Chronic tinnitus is a prevalent hearing disorder, and yet no successful treatments or
objective diagnostic tests are currently available. The aim of this study was to investigate the …

The impact of tinnitus distress on cognition

P Neff, J Simões, S Psatha, A Nyamaa, B Boecking… - Scientific reports, 2021 - nature.com
Tinnitus is the chronic perception of a phantom sound with different levels of related distress.
Past research has elucidated interactions of tinnitus distress with audiological, affective and …

Alterations in auditory brain stem response distinguish occasional and constant tinnitus

NK Edvall, G Mehraei, M Claeson… - The Journal of …, 2022 - Am Soc Clin Investig
BACKGROUND The heterogeneity of tinnitus is thought to underlie the lack of objective
diagnostic measures. METHODS Longitudinal data from 20,349 participants of the Swedish …

Auditory brainstem responses in tinnitus: a review of who, how, and what?

V Milloy, P Fournier, D Benoit, A Noreña… - Frontiers in aging …, 2017 - frontiersin.org
The auditory brainstem response (ABR) in tinnitus subjects has been extensively
investigated over the last decade with the hopes of finding possible abnormalities related to …