Selective estrogen receptor modulators (SERMs) are a diverse group of nonsteroidal
compounds that function as agonists or antagonists for estrogen receptors (ERs) in a target …

Endometrial cancer is the most common gynecological malignancy, with 41,000 new cases
projected in the United States for 2006. Two different clinicopathologic subtypes are …

Historical observations have suggested that endometrial carcinomas vary in histopathologic
appearance and clinical features. More recent, systematic studies have provided …

BACKGROUND The two most common types of uterine endometrial carcinoma,
endometrioid (UEC) and serous (USC), differ in their histopathologic appearance and …

The advent of next generation sequencing has vastly improved the resolution of mutation
detection, thereby both increasing the resolution of the analysis of cancer tissues and …

To elucidate the role of p53 abnormalities in endometrial tumorigenesis, a diverse group of
endometrial neoplasms and their putative precursors, atypical endometrial hyperplasia, and …

Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the
endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and β-catenin …

Endometrial carcinoma (EC) is the most common gynecological malignancy in the western
world. A widely accepted dualistic model, which has been established on a morphological …

Simple Summary Since the Kirsten rat sarcoma viral oncogene homolog (KRAS) is mutated
in about 25% of all human cancers and is at the center of pathways involved in …

In the Western world, endometrial carcinoma is the most common malignant tumour of the
female genital tract and the fourth most common cancer in women after carcinomas of …