Oleanolic acid, a pentacyclic triterpenoid ubiquitously present in the plant kingdom, is
receiving outstanding attention from the scientific community due to its biological activity …

Diabetes mellitus is one of the major health problems in the world, the incidence and
associated mortality are increasing. Inadequate regulation of the blood sugar imposes …

In this article, a series of betulinic acid derivatives (3a∼ 3u, 4a∼ 4e) were synthesized
through a stepwise structure optimization and evaluated for their anti-α-glucosidase …

Diabetes mellitus is a chronic metabolic disease which is a serious global problem. In 2010
an estimated 285 million people had diabetes and within the next 20 years this value is …

Pentacyclic triterpenoids including the oleanane, ursane and lupane groups are widely
distributed in many medicinal plants, such as Glycyrrhiza species, Gymnema species …

Oleanolic acid (OA), a natural component of many plant food and medicinal herbs, is
endowed with a wide range of pharmacological properties whose therapeutic potential has …

This article provides an overview of approximately 300 secondary metabolites with inhibitory
activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various …

Oleanolic (OA), ursolic (UA), and betulinic (BA) acids are three triterpenic acids (TAs) with
potential effects for treatment of type 2 diabetes (T2DM). Mechanistic studies showed that …

Introduction: Protein tyrosine phosphatase 1B (PTP1B) plays an important role in the
negative regulation of insulin signal transduction pathway and has emerged as novel …

背景目前已经证实植物来源的三萜齐墩果酸(oleanolic acid, OA) 具有降糖作用,
但是它对胰岛素信号级联传导途径的影响还没有被完全阐明. 当前这项研究的目的是在链脲霉素 …