Mistakenly thought to be the consequence of oxygen lack in contracting skeletal muscle we
now know that the L-enantiomer of the lactate anion is formed under fully aerobic conditions …

Once thought to be a waste product of anaerobic metabolism, lactate is now known to form
continuously under aerobic conditions. Shuttling between producer and consumer cells …

Impaired mitochondrial function often results in excessive production of reactive oxygen
species (ROS) and is involved in the etiology of many chronic diseases, including …

Skeletal muscle is a malleable tissue capable of altering the type and amount of protein in
response to disruptions to cellular homeostasis. The process of exerciseinduced adaptation …

Physical activity relies on muscular force. In adult skeletal muscle, force results from the
contraction of postmitotic, multinucleated myofibres of different contractile and metabolic …

Background It is clear that reactive oxygen species (ROS) produced during skeletal muscle
contraction have a regulatory role in skeletal muscle adaptation to endurance exercise …

Type 2 diabetes (T2D), one of the most prevalent noncommunicable diseases, is often
preceded by insulin resistance (IR), which underlies the inability of tissues to respond to …

Activation of AMP-activated protein kinase (AMPK) by exercise induces several cellular
processes in muscle. Exercise activation of AMPK is unaffected in lean (BMI∼ 25 kg/m2) …

Skeletal muscle has been emerging as a research field since the past 2 decades.
Contraction of a muscle, which acts as a secretory organ, stimulates production, secretion …

5′ AMP‐activated protein kinase (AMPK) is an energy sensor activated by perturbed
cellular energy status such as during muscle contraction. Activated AMPK is thought to …