Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is one of the most
abundant, long non-coding RNAs (lncRNAs) in normal tissues. This lncRNA is highly …

The CRISPR/Cas9 system has enabled efficient modification of genes in a variety of cellular
systems for studying phenotypic effects of genetic perturbations. However, with this …

Ninety-seven percent of drug-indication pairs that are tested in clinical trials in oncology
never advance to receive US Food and Drug Administration approval. While lack of efficacy …

Background: The molecular mechanism of tumorigenesis remains to be fully understood in
breast cancer. It is urgently required to identify genes that are associated with breast cancer …

CRISPR/Cas9 technology enables the rapid generation of loss‐of‐function mutations in a
targeted gene in mammalian cells. A single cell harboring those mutations can be used to …

High levels of cancer aneuploidy are frequently associated with poor prognosis. To examine
the relationship between aneuploidy and cancer progression, we analyzed a series of …

Two opposing viewpoints are held regarding the need for understanding a drug's molecular
target and mechanism of action. One extreme viewpoint is that it is unnecessary, because …

Background. Hepatocellular carcinoma (HCC) is one of the most prevalent cancers, and its
incidence rate is increasing worldwide. At present, there is no ideal treatment for HCC. In …

Complex, time-varying responses have been observed widely in cell signaling, but how
specific dynamics are generated or regulated is largely unknown. One major obstacle has …

Cancer 'genetic dependencies'—genes whose products are essential for cancer cell fitness—
are promising targets for therapeutic development. However, recent evidence has cast doubt …