The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …

Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Despite daily fasting and feeding, plasma glucose levels are normally maintained within a
narrow range owing to the hormones insulin and glucagon. Insulin increases glucose …

Glucose transport is rate limiting for dietary glucose utilization by muscle and fat. The
glucose transporter GLUT4 is dynamically sorted and retained intracellularly and …

Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most
prevalent diseases in the elderly population worldwide. A growing body of epidemiological …

The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes
of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver …

Rho GTPases are molecular switches that control a wide variety of signal transduction
pathways in all eukaryotic cells. They are known principally for their pivotal role in regulating …

Few physiological parameters are more tightly and acutely regulated in humans than blood
glucose concentration. The major cellular mechanism that diminishes blood glucose when …

Adipose tissue plays a significant role in whole body energy homeostasis. Obesity‐
associated diabetes, fatty liver and metabolic syndrome are closely linked to adipose stress …

The RAS oncogenes were identified almost 20 years ago. Since then, we have learnt that
they are members of a large family of small GTPases that bind GTP and hydrolyse it to GDP …