Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

PR Angelova, AY Abramov - FEBS letters, 2018 - Wiley Online Library
Mitochondria are key cell organelles in that they are responsible for energy production and
control many processes from signalling to cell death. The function of the mitochondrial …

Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

PR Angelova, N Esteras… - Medicinal Research …, 2021 - Wiley Online Library
The world's population aging progression renders age‐related neurodegenerative diseases
to be one of the biggest unsolved problems of modern society. Despite the progress in …

Four-repeat tauopathies

TW Roesler, AT Marvian, M Brendel… - Progress in …, 2019 - Elsevier
Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

[HTML][HTML] Genistein mitigates senescence of bone marrow mesenchymal stem cells via ERRα-mediated mitochondrial biogenesis and mitophagy in ovariectomized rats

M Li, Y Yu, K Xue, J Li, G Son, J Wang, W Qian… - Redox Biology, 2023 - Elsevier
Senescence of bone marrow mesenchymal stem cells (BMMSCs) induced by chronic
oxidative stress is an important factor contributes to the postmenopausal osteoporosis …

Mitochondria in cancer stem cells: Achilles heel or hard armor

X Zheng, J Chen, Y Sun, T Chen, J Wang, S Yu - Trends in Cell Biology, 2023 - cell.com
Previous studies have shown that mitochondria play core roles in not only cancer stem cell
(CSC) metabolism but also the regulation of CSC stemness maintenance and differentiation …

Nanorepairers rescue inflammation‐induced mitochondrial dysfunction in mesenchymal stem cells

Q Zhai, X Chen, D Fei, X Guo, X He, W Zhao… - Advanced …, 2022 - Wiley Online Library
Mitochondrial dysfunction in tissue‐specific mesenchymal stem cells (MSCs) plays a critical
role in cell fate and the morbidity of chronic inflammation‐associated bone diseases, such …

Interaction of oxidative stress and misfolded proteins in the mechanism of neurodegeneration

AY Abramov, EV Potapova, VV Dremin, AV Dunaev - Life, 2020 - mdpi.com
Aggregation of the misfolded proteins β-amyloid, tau, huntingtin, and α-synuclein is one of
the most important steps in the pathology underlying a wide spectrum of neurodegenerative …

Melatonin attenuates ER stress and mitochondrial damage in septic cardiomyopathy: a new mechanism involving BAP31 upregulation and MAPK‐ERK pathway

J Zhang, L Wang, W Xie, S Hu, H Zhou… - Journal of cellular …, 2020 - Wiley Online Library
Septic cardiomyopathy is associated with mitochondrial damage and endoplasmic reticulum
(ER) dysfunction. However, the upstream mediator of mitochondrial injury and ER stress has …

Recent advances in electrochemical sensors for the detection of biomolecules and whole cells

IR Suhito, KM Koo, TH Kim - Biomedicines, 2020 - mdpi.com
Electrochemical sensors are considered an auspicious tool to detect biomolecules (eg,
DNA, proteins, and lipids), which are valuable sources for the early diagnosis of diseases …

Mitophagy-driven metabolic switch reprograms stem cell fate

PP Naik, A Birbrair, SK Bhutia - Cellular and Molecular Life Sciences, 2019 - Springer
Abstract “Cellular reprogramming” facilitates the generation of desired cellular phenotype
through the cell fate transition by affecting the mitochondrial dynamics and metabolic …