Ubiquitination is one of the most conserved post-translational modifications and together
with mRNA translation contributes to cellular protein homeostasis (proteostasis). Temporal …

Background Hepatic inflammation is a common initiator of liver diseases and considered as
the primary driver of hepatocellular carcinoma (HCC). However, the precise mechanism of …

Protein ubiquitylation acts as a complex cell signaling mechanism since the formation of
different mono-and polyubiquitin chains determines the substrate's fate in the cell. E3 …

Lead (Pb) exposure causes immeasurable damage to multiple human systems, particularly
the central nervous system (CNS). In this study, human induced pluripotent stem cells …

Bone remodeling is a continuous process between bone-forming osteoblasts and bone-
resorbing osteoclasts, with any imbalance resulting in metabolic bone disease, including …

Sequence variants in the HERC2 gene are associated with a significant reduction in HERC2
protein levels and cause a neurodevelopmental disorder known as the HERC2-related …

HERC2 gene encodes an E3 ubiquitin ligase involved in several cellular processes by
regulating the ubiquitylation of different protein substrates. Biallelic pathogenic sequence …

Background Depression has been linked to ferritinophagy-induced synaptic damage, which
affects the emotional circuitry and can ultimately lead to depressive symptoms. It has been …

Ubiquitin ligases are important regulators of nervous system development, function and
disease. To date, numerous ubiquitin ligases have been discovered that regulate …

Human brain development involves a tightly regulated sequence of events that starts shortly
after conception and continues up to adolescence. Before birth, neurogenesis occurs …