[HTML][HTML] Applications of microfluidics and organ-on-a-chip in cancer research

S Regmi, C Poudel, R Adhikari, KQ Luo - Biosensors, 2022 - mdpi.com
Taking the life of nearly 10 million people annually, cancer has become one of the major
causes of mortality worldwide and a hot topic for researchers to find innovative approaches …

[HTML][HTML] Organ on chip technology to model cancer growth and metastasis

G Imparato, F Urciuolo, PA Netti - Bioengineering, 2022 - mdpi.com
Organ on chip (OOC) has emerged as a major technological breakthrough and distinct
model system revolutionizing biomedical research and drug discovery by recapitulating the …

[HTML][HTML] Mechanism underlying circRNA dysregulation in the TME of digestive system cancer

Z Wu, X Yu, S Zhang, Y He, W Guo - Frontiers in Immunology, 2022 - frontiersin.org
Circular RNAs (circRNAs) are a new series of noncoding RNAs (ncRNAs) that have been
reported to be expressed in eukaryotic cells and have a variety of biological functions in the …

Exosomes: Breast cancer-derived extracellular vesicles; recent key findings and technologies in disease progression, diagnostics, and cancer targeting

I Nakase, T Takatani-Nakase - Drug Metabolism and Pharmacokinetics, 2022 - Elsevier
Breast cancer is one of the most frequently diagnosed types of cancer in women. Metastasis,
particularly to the lungs and brain, increases mortality in breast cancer patients. Recently …

An Automation Workflow for High‐Throughput Manufacturing and Analysis of Scaffold‐Supported 3D Tissue Arrays

R Cao, NT Li, S Latour, JL Cadavid… - Advanced …, 2023 - Wiley Online Library
Patient‐derived organoids have emerged as a useful tool to model tumour heterogeneity.
Scaling these complex culture models while enabling stratified analysis of different cellular …

The WNK1–ERK5 route plays a pathophysiological role in ovarian cancer and limits therapeutic efficacy of trametinib

A Sánchez‐Fdez, S Matilla‐Almazán… - Clinical and …, 2023 - Wiley Online Library
Background The dismal prognosis of advanced ovarian cancer calls for the development of
novel therapies to improve disease outcome. In this regard, we set out to discover new …

[HTML][HTML] Reduction of metastasis via epigenetic modulation in a murine model of metastatic triple negative breast cancer (TNBC)

JLS Zylla, MM Hoffman, S Plesselova, S Bhattacharya… - Cancers, 2022 - mdpi.com
Simple Summary We investigate the use of the small molecule epigenetic modulator 4SC-
202 as a potential cancer therapeutic or adjuvant for Triple Negative Breast Cancer (TNBC) …

[HTML][HTML] Advances in 3D Culture Models to Study Exosomes in Triple-Negative Breast Cancer

NA Yousafzai, L El Khalki, W Wang, J Szpendyk… - Cancers, 2024 - mdpi.com
Simple Summary Breast cancer comes in different types, making it hard to treat effectively.
One particularly aggressive type, called triple-negative breast cancer, is tough to target with …

Well-orchestrated physico-chemical and biological factors for enhanced secretion of osteogenic and angiogenic extracellular vesicles by mesenchymal stem cells in a …

K Holkar, V Kale, G Ingavle - Biomaterials Science, 2022 - pubs.rsc.org
The secretome of mesenchymal stem cells (MSCs) is being studied for its regenerative
potential for the treatment of various disorders, including bone diseases. However …

[HTML][HTML] The road after cancer: biomaterials and tissue engineering approaches to mediate the tumor microenvironment post-cancer treatment

L Westwood, IJ Nixon, E Emmerson… - Frontiers in Biomaterials …, 2024 - frontiersin.org
Cancer affects tens of millions of the world's population each year with a stark mortality rate.
It is well established that in order to be effective in treating solid tumor cancers, the current …