Dyslipidemia in obesity: mechanisms and potential targets
B Klop, JWF Elte, M Castro Cabezas - Nutrients, 2013 - mdpi.com
Obesity has become a major worldwide health problem. In every single country in the world,
the incidence of obesity is rising continuously and therefore, the associated morbidity …
the incidence of obesity is rising continuously and therefore, the associated morbidity …
Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives
WS Harris, M Miller, AP Tighe, MH Davidson… - Atherosclerosis, 2008 - Elsevier
The most common omega-3 fatty acids contain 18–22 carbons and a signature double bond
at the third position from the methyl (or n, or omega) end of the molecule. These fatty acids …
at the third position from the methyl (or n, or omega) end of the molecule. These fatty acids …
Increase in long-chain polyunsaturated fatty acid n− 6/n− 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
Hepatic steatosis is a major feature associated with NAFLD (non-alcoholic fatty liver
disease). The aims of the present study were to assess the levels of PUFA (polyunsaturated …
disease). The aims of the present study were to assess the levels of PUFA (polyunsaturated …
Fish oil—how does it reduce plasma triglycerides?
GC Shearer, OV Savinova, WS Harris - … BBA)-Molecular and Cell Biology of …, 2012 - Elsevier
Long chain omega-3 fatty acids (FAs) are effective for reducing plasma triglyceride (TG)
levels. At the pharmaceutical dose, 3.4 g/day, they reduce plasma TG by about 25–50% after …
levels. At the pharmaceutical dose, 3.4 g/day, they reduce plasma TG by about 25–50% after …
Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis
Background Fish oil supplementation has been shown to be associated with a lower risk of
metabolic syndrome and benefit a wide range of chronic diseases, such as cardiovascular …
metabolic syndrome and benefit a wide range of chronic diseases, such as cardiovascular …
The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia
J Backes, D Anzalone, D Hilleman, J Catini - Lipids in Health and Disease, 2016 - Springer
Abstract Hypertriglyceridemia (triglycerides> 150 mg/dL) affects~ 25% of the United States
(US) population and is associated with increased cardiovascular risk. Severe …
(US) population and is associated with increased cardiovascular risk. Severe …
Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind …
MH Davidson, EA Stein, HE Bays, KC Maki, RT Doyle… - Clinical …, 2007 - Elsevier
Background: Patients with elevated serum triglyceride (TG) levels often have elevations in
non-high-density lipoprotein cholesterol (non-HDL-C) levels as well. The National …
non-high-density lipoprotein cholesterol (non-HDL-C) levels as well. The National …
Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial
JJP Kastelein, KC Maki, A Susekov, M Ezhov… - Journal of clinical …, 2014 - Elsevier
Background Omega-3 fatty acids in free fatty acid form have enhanced bioavailability, and
plasma levels are less influenced by food than for ethyl ester forms. Objective The aim was …
plasma levels are less influenced by food than for ethyl ester forms. Objective The aim was …
The ins and outs of endoplasmic reticulum‐controlled lipid biosynthesis
J Jacquemyn, A Cascalho, RE Goodchild - EMBO reports, 2017 - embopress.org
Endoplasmic reticulum (ER)‐localized enzymes synthesize the vast majority of cellular
lipids. The ER therefore has a major influence on cellular lipid biomass and balances the …
lipids. The ER therefore has a major influence on cellular lipid biomass and balances the …
Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications
HE Bays, AP Tighe, R Sadovsky… - Expert review of …, 2008 - Taylor & Francis
Hypertriglyceridemia is a risk factor for atherosclerotic coronary heart disease. Very high
triglyceride (TG) levels (≥ 500 mg/dl [5.65 mmol/l]) increase the risk of pancreatitis. One …
triglyceride (TG) levels (≥ 500 mg/dl [5.65 mmol/l]) increase the risk of pancreatitis. One …