The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …

In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

It is currently unclear how amyloid-β and tau deposition are linked to changes in synaptic
function and axonal structure over the course of Alzheimer's disease. Here, we assessed …

Alzheimer's disease is a progressive loss of memory and cognition, for which there is no
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's …

Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …

Alzheimer's disease (AD) is a devastating disease characterized by synaptic and neuronal
loss in the elderly. Compelling evidence suggests that soluble amyloid-β peptide (Aβ) …

Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …

β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying
Alzheimer's disease (AD), although there is presently lively debate regarding the relative …

Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central
nervous system, ranging from the regulation of gene transcription, cellular signaling …

Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …