Improved management of severe sepsis has been one of the major health care
accomplishments of the last two decades. Due to enhanced recognition and improved …

Skeletal muscle dysfunction after critical illness, defined as ICU-acquired weakness (ICU-
AW), is a complex and multifactorial syndrome that contributes significantly to long-term …

Background Various factors trigger the inflammatory response and cytokine activation in
skeletal muscle. Inflamed muscle will exhibit significant levels of inflammation and cytokine …

Sepsis survivors experience a persistent myopathy characterized by skeletal muscle
weakness, atrophy, and an inability to repair/regenerate damaged or dysfunctional …

The active participation of skeletal muscles is a unique characteristic of exertional heat
stroke. Nevertheless, the only well-documented link between skeletal muscle activities and …

The abundance, anatomical distribution, and vascularity of skeletal muscle make it a
potentially important contributor to local cytokine production and systemic cytokine …

Skeletal muscles secrete a wide variety of immunologically active cytokines, but the
functional significance of this response to in vivo innate immunity is not understood. We …

Muscle may contribute to the systemic inflammatory environment during critical illness, but
leukocyte interaction and cytokine influence on muscle and its response has not been fully …

Sepsis is a systemic inflammatory disorder that leads to the dysfunction of multiple organs. In
the intestine, the deregulation of the epithelial barrier contributes to the development of …

Sepsis induces a myopathy characterized by loss of muscle mass and weakness. Septic
patients undergo prolonged periods of limb muscle disuse due to bed rest. The contribution …