Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …

Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Malaria parasites break down host haemoglobin into peptides and amino acids in the
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …

Severe malaria caused by Plasmodium falciparum is difficult to diagnose accurately in
children in high-transmission settings. Using data from 2649 pediatric and adult patients …

We report an analysis of the propensity of the antimalarial agent cabamiquine, a
Plasmodium-specific eukaryotic elongation factor 2 inhibitor, to select for resistant …

The germ theory states that pathogenic microorganisms are responsible for causing
infectious diseases. The theory is inherently microbe-centric and does not account for …

Background Sickle cell anaemia (SCA) has historically been associated with high levels of
childhood mortality in Africa. Although malaria has a major contribution to this mortality, to …

Whole-genome sequencing (WGS) provides a comprehensive view of the genome, enabling
detection of coding and non-coding genetic variation, and surveying complex regions which …

Antagonistic coevolution (ie, reciprocal adaptation and counter-adaptation) between hosts
and pathogens has long been considered an important driver of genetic variation. However …

Understanding the genomic basis of infectious disease is a fundamental objective in co-
evolutionary theory with relevance to healthcare, agriculture, and epidemiology. Models of …