Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to …

JG Chase, JC Preiser, JL Dickson, A Pironet… - Biomedical engineering …, 2018 - Springer
Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …

Mathematical models and software tools for the glucose-insulin regulatory system and diabetes: an overview

A Makroglou, J Li, Y Kuang - Applied numerical mathematics, 2006 - Elsevier
An overview of some of the mathematical models appearing in the literature for use in the
glucose-insulin regulatory system in relation to diabetes is given, enhanced with a survey on …

Effects of dietary composition on energy expenditure during weight-loss maintenance

CB Ebbeling, JF Swain, HA Feldman, WW Wong… - Jama, 2012 - jamanetwork.com
Context Reduced energy expenditure following weight loss is thought to contribute to weight
gain. However, the effect of dietary composition on energy expenditure during weight-loss …

Meal simulation model of the glucose-insulin system

C Dalla Man, RA Rizza, C Cobelli - IEEE Transactions on …, 2007 - ieeexplore.ieee.org
A simulation model of the glucose-insulin system in the postprandial state can be useful in
several circumstances, including testing of glucose sensors, insulin infusion algorithms and …

Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites

B Lalovic, E Kharasch, C Hoffer, L Risler… - Clinical …, 2006 - Wiley Online Library
Background In vitro experiments suggest that circulating metabolites of oxycodone are
opioid receptor agonists. Clinical and animal studies to date have failed to demonstrate a …

Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance

R Basu, E Breda, AL Oberg, CC Powell… - Diabetes, 2003 - Am Diabetes Assoc
Glucose tolerance decreases with age. For determining the cause of this decrease, 67
elderly and 21 young (70.1±0.7 vs. 23.7±0.8 years) participants ingested a mixed meal and …

A system model of oral glucose absorption: validation on gold standard data

C Dalla Man, M Camilleri… - IEEE Transactions on …, 2006 - ieeexplore.ieee.org
A reliable model of glucose absorption after oral ingestion may facilitate simulation as well
as pathophysiological studies. One of the difficulties for the development and quality …

Oral glucose tolerance test minimal model indexes of β-cell function and insulin sensitivity

E Breda, MK Cavaghan, G Toffolo, KS Polonsky… - Diabetes, 2001 - Am Diabetes Assoc
The simultaneous assessment of quantitative indexes of insulin secretion and action in a
single individual is important when quantifying their relative role in the evolution of glucose …

Effects of age and sex on postprandial glucose metabolism: differences in glucose turnover, insulin secretion, insulin action, and hepatic insulin extraction

R Basu, C Dalla Man, M Campioni, A Basu, G Klee… - Diabetes, 2006 - Am Diabetes Assoc
To determine the effects of age and sex on the regulation of postprandial glucose
metabolism, glucose turnover, insulin secretion, insulin action, and hepatic insulin extraction …

Iodine biokinetics and dosimetry in radioiodine therapy of thyroid cancer: procedures and results of a prospective international controlled study of ablation after rhTSH …

H Hänscheid, M Lassmann, M Luster… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Technical aspects and results of the dosimetric assessments of postoperative radioiodine
ablation in the framework of an international, prospective, controlled, randomized …