Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Heparin-induced thrombocytopenia (HIT) is a life and limb-threatening complication of
heparin exposure. Here, we review the pathogenesis, incidence, diagnosis, and …

Drug-induced immune thrombocytopenia (DITP) is a life-threatening clinical syndrome that
is under-recognized and difficult to diagnose. Many drugs can cause immune-mediated …

The role of platelets in tumor progression and metastasis has been recognized but the
mechanism of their action remains unclear. Five human lung cancer cell lines (A549, CRL …

Although inflammation-induced thrombosis is a well-known entity, its pathogenesis remains
complicated. There are complex interactions between inflammation and hemostasis …

Microparticles are membrane vesicles released from many different cell types. There are two
mechanisms that can result in their formation, cell activation and apoptosis. In these two …

Considerable interest for cell-derived microparticles has emerged, pointing out their
essential role in haemostatic response and their potential as disease markers, but also their …

Clinical relevance of microparticles from platelets and mega... : Current Opinion in Hematology
Clinical relevance of microparticles from platelets and megakaryocytes : Current Opinion in …

Review Page 1 Review HEPARIN-INDUCED THROMBOCYTOPENIA: PATHOGENESIS AND
MANAGEMENT Heparin-induced thrombocytopenia (HIT) is a transient prothrombotic disorder …

Apoptosis and vascular cell activation are main contributors to the release of procoagulant
microparticles (MPs), deleterious partners in atherothrombosis. Elevated levels of circulating …