Bacteriophages and bacterial plant diseases
Losses in crop yields due to disease need to be reduced in order to meet increasing global
food demands associated with growth in the human population. There is a well-recognized …
food demands associated with growth in the human population. There is a well-recognized …
Unravelling the structural and mechanistic basis of CRISPR–Cas systems
Bacteria and archaea have evolved sophisticated adaptive immune systems, known as
CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR …
CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR …
Bacteriophages suppress CRISPR–Cas immunity using RNA-based anti-CRISPRs
Many bacteria use CRISPR–Cas systems to combat mobile genetic elements, such as
bacteriophages and plasmids. In turn, these invasive elements have evolved anti-CRISPR …
bacteriophages and plasmids. In turn, these invasive elements have evolved anti-CRISPR …
Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species
A Pawluk, RHJ Staals, C Taylor, BNJ Watson… - Nature …, 2016 - nature.com
CRISPR-Cas systems provide sequence-specific adaptive immunity against foreign nucleic
acids 1, 2. They are present in approximately half of all sequenced prokaryotes 3 and are …
acids 1, 2. They are present in approximately half of all sequenced prokaryotes 3 and are …
CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3
The prokaryotic CRISPR/Cas immune system is based on genomic loci that contain
incorporated sequence tags from viruses and plasmids. Using small guide RNA molecules …
incorporated sequence tags from viruses and plasmids. Using small guide RNA molecules …
Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands
RB Vercoe, JT Chang, RL Dy, C Taylor… - PLoS …, 2013 - journals.plos.org
In prokaryotes, clustered regularly interspaced short palindromic repeats (CRISPRs) and
their associated (Cas) proteins constitute a defence system against bacteriophages and …
their associated (Cas) proteins constitute a defence system against bacteriophages and …
Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs
Small RNAs target invaders for silencing in the CRISPR-Cas pathways that protect bacteria
and archaea from viruses and plasmids. The CRISPR RNAs (crRNAs) contain sequence …
and archaea from viruses and plasmids. The CRISPR RNAs (crRNAs) contain sequence …
Mechanism of foreign DNA selection in a bacterial adaptive immune system
In bacterial and archaeal CRISPR immune pathways, DNA sequences from invading
bacteriophage or plasmids are integrated into CRISPR loci within the host genome …
bacteriophage or plasmids are integrated into CRISPR loci within the host genome …
CRISPRTarget: bioinformatic prediction and analysis of crRNA targets
The bacterial and archaeal CRISPR/Cas adaptive immune system targets specific
protospacer nucleotide sequences in invading organisms. This requires base pairing …
protospacer nucleotide sequences in invading organisms. This requires base pairing …
A widespread bacteriophage abortive infection system functions through a Type IV toxin–antitoxin mechanism
RL Dy, R Przybilski, K Semeijn… - Nucleic acids …, 2014 - academic.oup.com
Bacterial abortive infection (Abi) systems are 'altruistic'cell death systems that are activated
by phage infection and limit viral replication, thereby providing protection to the bacterial …
by phage infection and limit viral replication, thereby providing protection to the bacterial …