Infectious agents and neurodegeneration
G De Chiara, ME Marcocci, R Sgarbanti, L Civitelli… - Molecular …, 2012 - Springer
A growing body of epidemiologic and experimental data point to chronic bacterial and viral
infections as possible risk factors for neurodegenerative diseases, including Alzheimer's …
infections as possible risk factors for neurodegenerative diseases, including Alzheimer's …
Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps
OA Levy, C Malagelada, LA Greene - Apoptosis, 2009 - Springer
Parkinson's disease (PD) is a common neurodegenerative disorder. Neuronal cell death in
PD is still poorly understood, despite a wealth of potential pathogenic mechanisms and …
PD is still poorly understood, despite a wealth of potential pathogenic mechanisms and …
Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans
D Raju, S Hussey, M Ang, MR Terebiznik, M Sibony… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: The Helicobacter pylori toxin vacuolating cytotoxin (VacA)
promotes gastric colonization, and its presence (VacA+) is associated with more-severe …
promotes gastric colonization, and its presence (VacA+) is associated with more-severe …
Induction of oxidative stress, lysosome activation and autophagy by nanoparticles in human brain-derived endothelial cells
B Halamoda Kenzaoui… - Biochemical …, 2012 - portlandpress.com
Different types of NPs (nanoparticles) are currently under development for diagnostic and
therapeutic applications in the biomedical field, yet our knowledge about their possible …
therapeutic applications in the biomedical field, yet our knowledge about their possible …
SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expression
CS Bartolomeo, RMR Lemes, RL Morais, GC Pereria… - Life sciences, 2022 - Elsevier
Aims This study evaluated SARS-CoV-2 replication in human cell lines derived from various
tissues and investigated molecular mechanisms related to viral infection susceptibility and …
tissues and investigated molecular mechanisms related to viral infection susceptibility and …
Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease
A Singanayagam, N Glanville, L Cuthbertson… - Science translational …, 2019 - science.org
Bacterial infection commonly complicates inflammatory airway diseases such as chronic
obstructive pulmonary disease (COPD). The mechanisms of increased infection …
obstructive pulmonary disease (COPD). The mechanisms of increased infection …
Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice
Y Mizunoe, Y Sudo, N Okita, H Hiraoka, K Mikami… - Autophagy, 2017 - Taylor & Francis
Whether obesity accelerates or suppresses autophagy in adipose tissue is still debatable.
To clarify dysregulation of autophagy and its role in pathologies of obese adipose tissue, we …
To clarify dysregulation of autophagy and its role in pathologies of obese adipose tissue, we …
Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice
T Wartmann, J Mayerle, T Kähne, M Sahin–Tóth… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Acute pancreatitis is characterized by an activation cascade of
digestive enzymes in the pancreas. The first of these, trypsinogen, can be converted to …
digestive enzymes in the pancreas. The first of these, trypsinogen, can be converted to …
Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer's disease
MI Islam, P Nagakannan, T Shcholok, F Contu… - Aging …, 2022 - Wiley Online Library
Experimental and clinical therapies in the field of Alzheimer's disease (AD) have focused on
elimination of extracellular amyloid beta aggregates or prevention of cytoplasmic neuronal …
elimination of extracellular amyloid beta aggregates or prevention of cytoplasmic neuronal …
Zinc (II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line
Abstract Treatment of MCF-7 cells with tamoxifen induced vacuole formation and cell death.
Levels of the autophagy marker, microtubule-associated protein light chain 3 (LC3)-II also …
Levels of the autophagy marker, microtubule-associated protein light chain 3 (LC3)-II also …