Beside cytotoxic drugs, other drugs can impact men's fertility through various mechanisms.
Via the modification of the hypothalamic–pituitary–gonadal axis hormones or by non …

Rapamycin (sirolimus) is a macrolide immunosuppressant that inhibits the mechanistic
target of rapamycin (mTOR) protein kinase and extends lifespan in model organisms …

Mammalian target of rapamycin (mTOR) inhibitors are used as potent immunosuppressive
agents in solid-organ transplant recipients (everolimus and sirolimus) and as antineoplastic …

Immunosuppressive drugs are used in the treatment of inflammatory and autoimmune
diseases, as well as in transplantation. Frequently prescribed in young people, these …

Clinical infertility is the inability of a couple to conceive after 12 months of trying. Male factors
are estimated to contribute to 30–50% of cases of infertility. Infertility or reduced fertility can …

The ovary contains oocytes within immature (primordial) follicles that are fixed in number at
birth. Activation of follicles within this fixed pool causes an irreversible decline in …

Background Codeine, a 3-methylmorphine, and other related opioids have been implicated
in androgen suppression, although the associated mechanisms remain unclear. Aim …

Although age‐related ovarian failure in female mammals cannot be reversed, recent
strategies have focused on improving reproductive capacity with age, and rapamycin is one …

Male factor accounts for about 30–50% of infertility. A common cause of male infertility is
drug abuse; either illicit or prolonged use of prescribed drugs. This study provides a review …

Spermatogenesis is a critical process for maintaining male fertility. Sustained
spermatogonial stem cell self-renewal and differentiation ensures constant …