Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …

Alterations of basal ganglia physiology in parkinsonism may consist of two elements, an
increase in the firing rate of neurones and a change in the pattern of synchronisation of …

The extent of synchronization within and between the nuclei of the basal ganglia is unknown
in Parkinson's disease. The question is an important one because synchronization will …

The basal ganglia (BG) are a highly organized network, where different parts are activated
for specific functions and circumstances. The BG are involved in movement control, as well …

There is a wealth of data suggesting that behavioural events are reflected in the basal
ganglia through phasic changes in the discharge of individual neurones. Here we …

Levodopa-induced motor complications are a common source of disability for patients with
Parkinson's disease. Evidence suggests that motor complications are associated with non …

To investigate the role of the basal ganglia in parkinsonian tremor, we recorded hand tremor
and simultaneous activity of several neurons in the external and internal segments of the …

Here we test the hypothesis that there are distinct temporal patterns of synchronized
neuronal activity in the pallidum that characterize untreated and treated parkinsonism and …

Modeling of the basal ganglia has played a major role in our understanding of this elusive
group of nuclei. Models of the basal ganglia have undergone evolutionary and revolutionary …

The pathophysiology of levodopa-induced dyskinesias (LID) in Parkinson's disease is not
well understood. We have recorded local field potentials (LFP) from macroelectrodes …