DNA damage, and repair in mutagenesis and carcinogenesis: implications of structure-activity relationships for cross-species extrapolation
EW Vogel, MJM Nivard, LAB Ballering… - Mutation Research …, 1996 - Elsevier
Previous studies on structure-activity relationships (SARs) between types of DNA
modifications and tumour incidence revealed linear positive relationships between the log …
modifications and tumour incidence revealed linear positive relationships between the log …
Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11
CWO het Veld, J Jansen, MZ Zdzienicka… - Mutation Research …, 1998 - Elsevier
The Chinese hamster cell mutant EM-C11, which is hypersensitive to the cell killing effects of
alkylating agents compared to its parental line CHO9, has been used to study the impact of …
alkylating agents compared to its parental line CHO9, has been used to study the impact of …
The cross-linking agent hexamethylphosphoramide predominantly induces intra-locus and multi-locus deletions in postmeiotic germ cells of Drosophila.
I Aguirrezabalaga, MJ Nivard, MA Comendador… - Genetics, 1995 - academic.oup.com
The nature of DNA sequence changes induced by the cross-linking agent
hexamethylphosphoramide (HMPA) within and in the vicinity of the vermilion locus of …
hexamethylphosphoramide (HMPA) within and in the vicinity of the vermilion locus of …
In vivo repair of ENU-induced oxygen alkylation damage by the nucleotide excision repair mechanism in Drosophila melanogaster
L Tosal, MA Comendador, LM Sierra - Molecular Genetics and Genomics, 2001 - Springer
DNA damage caused by oxygen alkylation of bases (mainly at O 6-G, O 4-T and O 2-T
positions in DNA) has been correlated with the mutagenic and carcinogenic potency of …
positions in DNA) has been correlated with the mutagenic and carcinogenic potency of …
Mutational spectra induced under distinct excision repair conditions by the 3 methylating agents N-methyl-N-nitrosourea, N-methyl-N′-nitro-N-nitrosoguanidine and …
MJM Nivard, A Pastink, EW Vogel - Mutation Research/Fundamental and …, 1996 - Elsevier
This paper describes the analysis of mutations induced at the vermilion locus in postmeiotic
male germ cell stages of Drosophila exposed to 3 different N-methyl-N-nitroso compounds …
male germ cell stages of Drosophila exposed to 3 different N-methyl-N-nitroso compounds …
Induced mutagenic effects in the nucleotide excision repair deficient Drosophila mutant mus201D1, expressing a truncated XPG protein
FMGR Calléja, MJM Nivard, JCJ Eeken - Mutation Research/DNA Repair, 2001 - Elsevier
Defects in nucleotide excision repair (NER) as defined by the UV sensitivity of xeroderma
pigmentosum (XP), Cockayne syndrome (CS) and trichothiodystrophy (TTD) patients has …
pigmentosum (XP), Cockayne syndrome (CS) and trichothiodystrophy (TTD) patients has …
Female germ cell mutagenicity of model chemicals in Drosophila melanogaster: mechanistic information and analysis of repair systems
J Hernando, L Álvarez, JA Ferreiro, I Sancho… - Mutation Research …, 2004 - Elsevier
In spite of differences between female and male germ cells, and although both of them
contribute to the gene pool of future generations, most germ cell mutagenicity studies in …
contribute to the gene pool of future generations, most germ cell mutagenicity studies in …
The mus308 locus of Drosophila melanogaster is implicated in the bypass of ENU-induced O-alkylpyrimidine adducts
L Tosal, MA Comendador, LM Sierra - Molecular and General Genetics …, 2000 - Springer
The mus308 locus of D. melanogaster was originally characterized by virtue of a mutant
phenotype that resulted in specific hypersensitivity to cross-linking agents. However, the …
phenotype that resulted in specific hypersensitivity to cross-linking agents. However, the …
Evaluation of the database on mutant frequencies and DNA sequence alterations of vermilion mutations induced in germ cells of Drosophila shows the importance of …
MJM Nivard, I Aguirrezabalaga, LAP Ballering… - Mutation Research …, 1999 - Elsevier
The vermilion gene in Drosophila has extensively been used for the molecular analysis of
mutations induced by chemicals in germ cells in vivo. The gene is located on the X …
mutations induced by chemicals in germ cells in vivo. The gene is located on the X …
The importance of distinct metabolites of N-nitrosodiethylamine for its in vivo mutagenic specificity
LM Sierra, L Tosal, MJM Nivard… - Mutation Research …, 2001 - Elsevier
Although N-nitrosodiethylamine (NDEA) is a potent carcinogen in rodents and a probable
human carcinogen, little attempts were made to characterize its mutation spectrum in higher …
human carcinogen, little attempts were made to characterize its mutation spectrum in higher …