The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

The link between diabetes mellitus and tuberculosis has been recognised for centuries. In
recent decades, tuberculosis incidence has declined in high-income countries, but …

Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an important drug-
metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to …

Objectives To review the current knowledge about tuberculosis (TB) and diabetes,
assessing the implication of the global increase of diabetes for TB control and patient care …

Sucralose is a synthetic organochlorine sweetener (OC) that is a common ingredient in the
world's food supply. Sucralose interacts with chemosensors in the alimentary tract that play a …

Rifampicin, an important drug in the treatment of tuberculosis, is used extensively despite its
broad effects on drug-drug interactions, creating serious problems. The clinical importance …

Abstract Cytochrome P450 (CYP) induction-mediated interaction is one of the major
concerns in clinical practice and for the pharmaceutical industry. There are two major issues …

In various embodiments, the present invention provides methods of reducing the risk of a
cardiovascular event in a subject on statin therapy and, in particular, a method of reducing …

There is a rising worldwide prevalence of diabetes, especially type 2 diabetes mellitus (T 2
DM), which is one of the most challenging health problems in the 21st century. The …