The Bacillus cereus group includes several Bacillus species with closely related phylogeny.
The most well-studied members of the group, B. anthracis, B. cereus, and B. thuringiensis …

Bacterial sepsis is a major cause of fatality worldwide. Sepsis is a multi-step process that
involves an uncontrolled inflammatory response by the host cells that may result in multi …

Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …

Inflammasomes are cytosolic multiprotein complexes that assemble in response to a variety
of infectious and noxious insults. Inflammasomes play a critical role in the initiation of innate …

Anthrax is caused by the spore-forming, gram-positive bacterium Bacillus anthracis. The
bacterium's major virulence factors are (a) the anthrax toxins and (b) an antiphagocytic …

Anthrax lethal toxin, produced by the bacterium Bacillus anthracis, is the major cause of
death in animals infected with anthrax. One component of this toxin, lethal factor (LF), is …

Pore-forming protein toxins (PFTs) are one of Nature's most potent biological weapons. An
essential feature of their toxicity is the remarkable property that PFTs can exist either in a …

Certain pathogenic species of Bacillus and Clostridium have developed unique methods for
intoxicating cells that employ the classic enzymatic “AB” paradigm for protein toxins. The …

Lethal factor (LF) is the major virulence factor produced byBacillus anthracis. LF is sufficient
to cause death in laboratory animals and cytolysis of peritoneal macrophages and …

Lethal factor (LF) is a protein (relative molecular mass 90,000) that is critical in the
pathogenesis of anthrax,,. It is a highly specific protease that cleaves members of the …