Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …

Myoblast fusion is a critical process that contributes to the growth of muscle during
development and to the regeneration of myofibers upon injury. Myoblasts fuse with each …

Skeletal muscle has a remarkable ability to respond to different physical stresses. Loading
muscle through exercise, either anaerobic or aerobic, can lead to increases in muscle size …

Polycations are useful delivery vehicles for nucleic acids and proteins. Physicochemical
properties, safety, and cost are important design parameters for polycation-enabled …

Heparan sulfate proteoglycans (HSPG) are macromolecular glyco-conjugates expressed
ubiquitously on the cell surface and in the extracellular matrix where they interact with a …

Background A high glucose level is usually considered to be the factor that induces tissue
and cell dysfunction and damage, commonly known as “glucose toxicity”. Objective This …

This study reviewed some new aspects of the modular proteoglycan perlecan, a colossal
proteoglycan with a 467 kDa core protein and five distinct functional domains. Perlecan is a …

Muscle degeneration is the most prevalent cause for frailty and dependency in inherited
diseases and ageing. Elucidation of pathophysiological mechanisms, as well as effective …

Heparan sulfate (HS) is a complex linear polysaccharide that modulates a wide range of
biological functions. Elucidating the structure–function relationship of HS has been …

The biological properties of Heparan sulfate (HS) polysaccharides essentially rely on their
ability to bind and modulate a multitude of protein ligands. These interactions involve …