Nanoparticles in drug delivery: From history to therapeutic applications

O Afzal, ASA Altamimi, MS Nadeem, SI Alzarea… - Nanomaterials, 2022 - mdpi.com
Current research into the role of engineered nanoparticles in drug delivery systems (DDSs)
for medical purposes has developed numerous fascinating nanocarriers. This paper reviews …

Applications of phyto-nanotechnology for the treatment of neurodegenerative disorders

T Bhattacharya, GAB Soares, H Chopra, MM Rahman… - Materials, 2022 - mdpi.com
The strategies involved in the development of therapeutics for neurodegenerative disorders
are very complex and challenging due to the existence of the blood-brain barrier (BBB), a …

Piperine: A review of its biological effects

IU Haq, M Imran, M Nadeem, T Tufail… - Phytotherapy …, 2021 - Wiley Online Library
Medicinal plants have been used for years as a source of food, spices, and, in traditional
medicine, as a remedy to numerous diseases. Piper nigrum, belonging to the family …

Solid lipid nanoparticles (SLNs): an advanced drug delivery system targeting brain through BBB

MK Satapathy, TL Yen, JS Jan, RD Tang, JY Wang… - Pharmaceutics, 2021 - mdpi.com
The blood–brain barrier (BBB) plays a vital role in the protection and maintenance of
homeostasis in the brain. In this way, it is an interesting target as an interface for various …

Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases

C Tapeinos, M Battaglini, G Ciofani - Journal of Controlled Release, 2017 - Elsevier
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) comprise a
category of versatile drug delivery systems that have been used in the biomedical field for> …

Piperine—the bioactive compound of black pepper: from isolation to medicinal formulations

L Gorgani, M Mohammadi… - … reviews in food …, 2017 - Wiley Online Library
Piperine is the major bio‐active component of pepper, which imparts pungency and biting
taste to it. This naturally occurring alkaloid has numerous demonstrated health effects and …

Drug delivery to the central nervous system by polymeric nanoparticles: what do we know?

J Kreuter - Advanced drug delivery reviews, 2014 - Elsevier
Nanoparticles enable the delivery of a great variety of drugs including anticancer drugs,
analgesics, anti-Alzheimer's drugs, cardiovascular drugs, protease inhibitors, and several …

Nanotechnology-based drug delivery systems for the treatment of Alzheimer's disease

B Fonseca-Santos, MPD Gremião… - International Journal of …, 2015 - Taylor & Francis
Alzheimer's disease is a neurological disorder that results in cognitive and behavioral
impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs …

Nanodelivery of natural antioxidants: an anti-aging perspective

A Vaiserman, A Koliada, A Zayachkivska… - … in bioengineering and …, 2020 - frontiersin.org
The aging process is known to be associated with heightened oxidative stress and related
systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising …

Intranasal piperine-loaded chitosan nanoparticles as brain-targeted therapy in Alzheimer's disease: optimization, biological efficacy, and potential toxicity

YSR Elnaggar, SM Etman, DA Abdelmonsif… - Journal of …, 2015 - Elsevier
Piperine (PIP) is a phytopharmaceutical with reported neuroprotective potential in
Alzheimer's disease (AD). Oral PIP delivery suffers from its hydrophobicity and pre-systemic …