The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …

Carcinogenesis is a multistep process involving mutation and the subsequent selective
clonal expansion of the mutated cell. Chemical and physical agents including those that …

Reactive oxygen species (ROS) are induced through a variety of endogenous and
exogenous sources. Overwhelming of antioxidant and DNA repair mechanisms in the cell by …

Abstract APE1/Ref-1 (APE1), the mammalian ortholog of Escherichia coli Xth, and a
multifunctional protein possessing both DNA repair and transcriptional regulatory activities …

Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and
are suggested to be related to cancer risk. However, epidemiologic findings have been …

Increasing numbers of cancer patients survive and live longer than five years after therapy,
but very often side effects of cancer treatment arise at same time. One of the side effects …

Neuronal DNA repair remains one of the most exciting areas for investigation, particularly as
a means to compare the DNA repair response in mitotic (cancer) vs. post-mitotic (neuronal) …

Significance: Mitochondria are fundamental to the life and proper functioning of cells. These
organelles play a key role in energy production, in maintaining homeostatic levels of second …

Oxidative DNA damage is implicated in brain aging, neurodegeneration and neurological
diseases. Damage can be created by normal cellular metabolism, which accumulates with …

The DNA base excision-repair pathway is responsible for the repair of DNA damage caused
by oxidation/alkylation and protects cells against the effects of endogenous and exogenous …