Synthesizing biomaterials in living organisms

X Zhang, J Wang, Y Zhang, Z Yang, J Gao… - Chemical Society …, 2023 - pubs.rsc.org
Living organisms fabricate biomacromolecules such as DNA, RNA, and proteins by the self-
assembly process. The research on the mechanism of biomacromolecule formation also …

DNA Origami: From Molecular Folding Art to Drug Delivery Technology

Q Jiang, Y Shang, Y Xie, B Ding - Advanced Materials, 2024 - Wiley Online Library
DNA molecules that store genetic information in living creatures can be repurposed as
building blocks to construct artificial architectures, ranging from the nanoscale to the …

Creating complex protocells and prototissues using simple DNA building blocks

N Arulkumaran, M Singer, S Howorka… - Nature …, 2023 - nature.com
Building synthetic protocells and prototissues hinges on the formation of biomimetic skeletal
frameworks. Recreating the complexity of cytoskeletal and exoskeletal fibers, with their …

Coacervate droplets for synthetic cells

Z Lin, T Beneyton, JC Baret, N Martin - Small Methods, 2023 - Wiley Online Library
The design and construction of synthetic cells–human‐made microcompartments that mimic
features of living cells–have experienced a real boom in the past decade. While many efforts …

Dynamic reconfigurable DNA nanostructures, networks and materials

J Wang, Z Li, I Willner - Angewandte Chemie, 2023 - Wiley Online Library
DNA nanotechnology relies on the structural and functional information encoded in nucleic
acids. Specifically, the sequence‐guided reconfiguration of nucleic acids by auxiliary …

Mesoporous nanozyme-enhanced DNA tetrahedron electrochemiluminescent biosensor with three-dimensional walking nanomotor-mediated CRISPR/Cas12a for …

B Shen, L Li, C Liu, X Li, X Li, X Cheng, H Wu… - Analytical …, 2023 - ACS Publications
Exosomal microRNAs (exomiRNAs) have emerged as ideal biomarkers for early clinical
diagnostics. The accurate detection of exomiRNAs plays a crucial role in facilitating clinical …

Present and future of synthetic cell development

KP Adamala, M Dogterom, Y Elani, P Schwille… - … Reviews Molecular Cell …, 2024 - nature.com
Scientists are captivated by the prospect of creating a fully synthetic cell, offering the
potential to revolutionize biology, medicine and biotechnology. In this Viewpoint, a panel of …

Modulating the lifetime of DNA motifs using visible light and small molecules

L Wimberger, FJ Rizzuto, JE Beves - Journal of the American …, 2023 - ACS Publications
Here we regulate the formation of dissipative assemblies built from DNA using a
merocyanine photoacid that responds to visible light. The operation of our system and the …

Protease-triggered, spatially controlled DNA assembly in apoptotic cells for early evaluation of therapeutic efficacy

Z Di, X Yi, L Li - Journal of the American Chemical Society, 2023 - ACS Publications
Despite numerous advances in the use of DNA as building blocks to assemble complex
structures, the dearth of strategies that allow for protease-controlled in situ DNA assembly in …

Functionalization and higher-order organization of liposomes with DNA nanostructures

Z Zhang, Z Feng, X Zhao, D Jean, Z Yu… - Nature …, 2023 - nature.com
Small unilamellar vesicles (SUVs) are indispensable model membranes, organelle mimics,
and drug and vaccine carriers. However, the lack of robust techniques to functionalize or …